Efficacy of a basal insulin dose management smartphone application for controlling fasting blood glucose in patients with type-2 diabetes mellitus: A single-centre, randomised clinical study

• Published in: Clinical endocrinology (Oxford) 2023-10, Vol.99 (4), p.361-369
• Main Authors: Luo, Ensi, Wan, Jiejun, Su, Minting, Wang, Jieying, Feng, Jiahua, Xie, Xia, Hong, Xiaocheng
• Format: Article
• Language: English
• Subjects: Blood glucose; Diabetes; Diabetes mellitus; Fasting; Glucose; Hypoglycemia; Insulin; Patients; Titration
• ISSN: 0300-0664; 1365-2265
• DOI: 10.1111/cen.14956

To explore the efficacy and safety of the 'Walk with you' application for titrating basal insulin (BI) doses in type-2 diabetes mellitus (T2DM) hospitalised patients. This was a randomised, single-centre, open-label, controlled clinical trial to compare the changes in fasting blood glucose (FBG) and postprandial blood glucose (PBG), time to reach target FBG (FBG-TRT), incidence of hypoglycaemia events and FBG coefficient of variation in the application group (weight-based titration of BI dose regimen) and control group (typical adjustment regimen). This study selected 173 patients with T2DM using basal-prandial insulin therapy who were admitted to Binhaiwan Central Hospital of Dongguan between December 2021 and December 2022. Patients were randomised to the control group or the application group (App group) and then titrated to achieve an FBG concentration of less than 7.0 mmol/L. There were 86 patients in the control group and 87 patients in the App group. The FBG concentrations in the control and App groups were decreased by 6.77 ± 4.75 and 5.95 ± 4.06 mmol/L, respectively. The FBG-TRTs in the control and App groups were 3.80 ± 1.52 and 2.82 ± 1.34 days, respectively (p