Association of Helicobacter pylori with migraine headaches and the effects of this infection and its eradication on the migraine characteristics in adults: A comprehensive systematic review and meta‐analysis

Background Migraine is one of the most common neurological disorders that can severely overshadow people's quality of life, and Helicobacter pylori infection is a health problem in different societies. During the last two decades, many original studies have been conducted on the various aspects...

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Bibliographic Details
Published in:Helicobacter (Cambridge, Mass.) Mass.), 2023-10, Vol.28 (5), p.e13010-n/a
Main Authors: Bawand, Rashed, Ghiasian, Masoud, Samadyan, Mustapha, Qaderi, Sorush
Format: Article
Language:English
Subjects:
Adults
Clinical trials
Eradication
H. pylori
Headache
Headaches
Helicobacter pylori
Heterogeneity
Infections
Meta-analysis
Migraine
Neurological diseases
Oxidative stress
Patients
Quality of life
review
Signs and symptoms
Statistical analysis
Subgroups
Substantia alba
Trinucleotide repeats
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Summary:Background Migraine is one of the most common neurological disorders that can severely overshadow people's quality of life, and Helicobacter pylori infection is a health problem in different societies. During the last two decades, many original studies have been conducted on the various aspects of the relationship between these two disorders; however, they have reported different and sometimes contradictory results. Methods This study was conducted based on the PRISMA protocol. We performed a comprehensive literature search in the online databases up to May 2023, and 22 studies that contained original data on the relationship between H. pylori infection and migraine headaches in adults were included. For performing the meta‐analysis, we calculated the odds ratios (OR) and 95% confidence intervals (CI), using a random‐effects model, and to determine the possible causes of heterogeneity, we conducted a subgroup meta‐analysis. Results The overall OR for the association of H. pylori infection and migraine headaches through 493,794 evaluated individuals was 2.80 [95% CI = 1.75–4.48; I2 = 89.20, p 
ISSN:1083-4389
1523-5378
DOI:10.1111/hel.13010