Correlation of vitamin D receptor genotypes, specific IgE levels and other variables with asthma control in children

Asthma is a common condition affecting millions of children globally. The main goal of this study is to assess factors related to asthma management, particularly atopy level and the impact of genetic variants of the vitamin D receptor (VDR) gene. Asthmatic children were enrolled in an outpatient res...

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Published in:The Journal of asthma 2024-02, Vol.61 (2), p.105-118
Main Authors: Al-Qerem, Walid, Jarab, Anan, Jarrar, Yazun, Al-Zayadneh, Enas, Al-Iede, Montaha, Ling, Jonathan, Abu Hammour, Khawla, S Alabdullah, Sally, Saad Alabdullah, Asal, Al Refaie, Yamam, Lubbad, Dina, Alassi, Ameen, Ibrahim, Sarah, Al-Ibadah, Mahmood, Al Bawab, Abdel Qader
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
Anti-Asthmatic Agents - therapeutic use
Asthma - drug therapy
Asthma - genetics
Child
Female
Genotype
Humans
Immunoglobulin E
Male
Receptors, Calcitriol - genetics
Receptors, Calcitriol - therapeutic use
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Summary:Asthma is a common condition affecting millions of children globally. The main goal of this study is to assess factors related to asthma management, particularly atopy level and the impact of genetic variants of the vitamin D receptor (VDR) gene. Asthmatic children were enrolled in an outpatient respiratory clinic. Information on patients' medication adherence, medical and medication factors, and sociodemographic were gathered. Spirometry FEV1% and FVC% measurements, and the asthma control test were used to evaluate the severity of asthma, and genotyping of the VDR gene and radioallergosorbent test (RAST) were conducted. Regression analyses were conducted to evaluate variables associated with asthma control and spirometry measures. A total of 313 participants (67.4% males) were recruited in the current study. The mean age was 9.37 (±3.45) years. The mean score for adherence was 4.26 (±2.52), and only 46% of the participants had controlled asthma. Forward conditional stepwise binary regression showed that low and moderate Inhaled corticosteroids (ICS) dose (OR= 0.42 (95% CI 0.20-0.90),  = 0.026; OR = 0.371 (95% CI 0.2-0.72),  = 0.003, respectively) decreased the odds of being in the controlled asthma group, while higher inhaler score (OR = 2.75 (95% CI 2.17-3.49,  
ISSN:0277-0903
1532-4303
DOI:10.1080/02770903.2023.2244580