A biochemomechanical model of collagen turnover in arterial adaptations to hemodynamic loading

The production, removal, and remodeling of fibrillar collagen is fundamental to mechanical homeostasis in arteries, including dynamic morphological and microstructural changes that occur in response to sustained changes in blood flow and pressure under physiological conditions. These dynamic process...

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Bibliographic Details
Published in:Biomechanics and modeling in mechanobiology 2023-12, Vol.22 (6), p.2063-2082
Main Authors: Tilahun, Hailu G., Mullagura, Haritha N., Humphrey, Jay D., Baek, Seungik
Format: Article
Language:English
Subjects:
Adaptation
Animal models
Arteries
Biological activity
Biological and Medical Physics
Biomedical Engineering and Bioengineering
Biophysics
Blood flow
Blood pressure
Collagen
Constitutive relationships
Engineering
Fibers
Hemodynamics
Homeostasis
Microfibrils
Original Paper
Procollagen
Simulation
Theoretical and Applied Mechanics
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Summary:The production, removal, and remodeling of fibrillar collagen is fundamental to mechanical homeostasis in arteries, including dynamic morphological and microstructural changes that occur in response to sustained changes in blood flow and pressure under physiological conditions. These dynamic processes involve complex, coupled biological, chemical, and mechanical mechanisms that are not completely understood. Nevertheless, recent simulations using constrained mixture models with phenomenologically motivated constitutive relations have proven able to predict salient features of the progression of certain vascular adaptations as well as disease processes. Collagen turnover is modeled, in part, via stress-dependent changes in collagen half-life, typically within the range of 10–70 days. By contrast, in this work we introduce a biochemomechanical approach to model the cellular synthesis of procollagen as well as its transition from an intermediate state of assembled microfibrils to mature cross-linked fibers, with mechano-regulated removal. The resulting model can simulate temporal changes in geometry, composition, and stress during early vascular adaptation (weeks to months) for modest changes in blood flow or pressure. It is shown that these simulations capture salient features from data presented in the literature from different animal models.
ISSN:1617-7959
1617-7940
DOI:10.1007/s10237-023-01750-1