Relationship between systemic immune inflammation index and amputation in patients with diabetic foot ulcer

• Published in: Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2024-07, Vol.29 (4), p.1060-1063
• Main Authors: Aydın, Mehmet Salih, Eren, Mehmet Ali, Uyar, Nida, Kankılıç, Nazım, Karaaslan, Hüseyin, Sabuncu, Tevfik, Çelik, Hakim
• Format: Article
• Language: English
• Subjects: Aged; Amputation, Surgical; Biomarkers - blood; Diabetes mellitus; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - immunology; Diabetes Mellitus, Type 2 - surgery; Diabetic Foot - blood; Diabetic Foot - immunology; Diabetic Foot - surgery; Female; Foot; Humans; Inflammation; İnflammation parameters; Lymphocyte Count; Lymphocytes - immunology; Male; Middle Aged; Neutrophils; Platelet Count; Retrospective Studies
• ISSN: 0949-2658; 1436-2023; 1436-2023
• DOI: 10.1016/j.jos.2023.07.015

The systemic immune inflammation index (SII) is a cost-effective biomarker calculated by lymphocyte, neutrophil and platelet counts and is currently being studied in various diseases. Since there is no study examining the relationship between SII and diabetic foot ulcers (DFU) in the literature, our aim was to investigate the relationship between SII and amputation rate in DFU. Type 2 DM 511 patients with DFU were screened from 2017 to 2021. Laboratory data obtained on the first day of hospitalization were considered. Platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR) and SII were calculated from routine blood count. Participants were divided into two groups as amputation (Group 1) and non-amputation (Group 2). Amputation rate was 18.8%. The A1c (8.80 (3.26) % vs. 9.52 (3.10) %, p = 0.007) and HGB (10.17 ± 2.16 g/dL vs. 12.05 ± 2.20 g/dL, p