Insect transient receptor potential vanilloid channels as potential targets of insecticides

• Published in: Developmental and comparative immunology 2023-11, Vol.148, p.104899-104899, Article 104899
• Main Authors: Huang, Zengqing, Sun, Zhonghe, Liu, Jiayi, Ju, Xiaoli, Xia, Hengchuan, Yang, Yanhua, Chen, Keping, Wang, Qiang
• Format: Article
• Language: English
• Subjects: Chordotonal organ; Insect; Insecticide; TRPV
• ISSN: 0145-305X; 1879-0089
• DOI: 10.1016/j.dci.2023.104899

Chordotonal organs are miniature sensory organs present in insects. Chordotonal organs depend on transient receptor potential (TRP) channels. Transient receptor potential vanilloid (TRPV) channels are the only TRPs identified that can act as targets of insecticides. By binding with TRPV channels, insecticides targeting the chordotonal organs trigger the inflow of calcium ions, resulting in abnormal function of the chordotonal organ to achieve the goal of eliminating pests. TRPV channels are highly expressed in various developmental stages and tissue parts of insects and play an important role in the whole life history of insects. In this review, we will discuss the structure and types of TRPV channels as well as their genetic relationships in different species. We also systematically reviewed the recent progress of TRPV channels as insecticide targets, demonstrating that TRPV channels can be used as the target of new high-efficiency insecticides. •The structure and mechanism of TRPV ion channels are described in detail.•Summarize the research progress of several insecticides targeting TRPV ion channels.•The insecticides targeting TRPV ion channel have high specificity and good insecticidal effect on resistant insecticides.