Engineering nanoparticle toolkits for mRNA delivery

The concept of using mRNA to produce its own medicine in situ in the body makes it an ideal drug candidate, holding great potential to revolutionize the way we approach medicine. The unique characteristics of mRNA, as well as its customizable biomedical functions, call for the rational design of del...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2023-09, Vol.200, p.115042-115042, Article 115042
Main Authors: Sun, Bing, Wu, Weixi, Narasipura, Eshan A, Ma, Yutian, Yu, Chengzhong, Fenton, Owen S, Song, Hao
Format: Article
Language:English
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Summary:The concept of using mRNA to produce its own medicine in situ in the body makes it an ideal drug candidate, holding great potential to revolutionize the way we approach medicine. The unique characteristics of mRNA, as well as its customizable biomedical functions, call for the rational design of delivery systems to protect and transport mRNA molecules. In this review, a nanoparticle toolkit is presented for the development of mRNA-based therapeutics from a drug delivery perspective. Nano-delivery systems derived from either natural systems or chemical synthesis, in the nature of organic or inorganic materials, are summarised. Delivery strategies in controlling the tissue targeting and mRNA release, as well as the role of nanoparticles in building and boosting the activity of mRNA drugs, will also be introduced. Finally, our insights into the clinical and translational development of mRNA nano-drugs are presented.
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2023.115042