Periocular methotrexate versus periocular triamcinolone injections for active thyroid-associated orbitopathy: a randomized clinical trial

Purpose To assess the efficacy and safety of periocular injections of methotrexate versus triamcinolone in the management of active thyroid-associated orbitopathy. Study design Prospective, double-masked, randomized clinical trial. Methods Participants with bilateral active, moderate-to-severe thyro...

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Bibliographic Details
Published in:Japanese journal of ophthalmology 2023-11, Vol.67 (6), p.699-710
Main Authors: Swaify, Islam Y., Nasr, Haytham E., El Essawy, Rania A., Elessawy, Kareem B.
Format: Article
Language:English
Subjects:
Apertures
Atrophy
Clinical Investigation
Clinical trials
Complications
Intraocular pressure
Medicine
Medicine & Public Health
Methotrexate
Ophthalmology
Reduction
Soft tissues
Statistical analysis
Thyroid
Thyroid gland
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Summary:Purpose To assess the efficacy and safety of periocular injections of methotrexate versus triamcinolone in the management of active thyroid-associated orbitopathy. Study design Prospective, double-masked, randomized clinical trial. Methods Participants with bilateral active, moderate-to-severe thyroid-associated orbitopathy were randomly assigned to receive three periocular injections of 7.5 mg methotrexate in one orbit and three periocular injections of 20 mg triamcinolone in the contralateral orbit. Results Among the enrolled 25 patients, 18 patients completed the study. A statistically significant reduction of the mean clinical activity score was detected in both arms (from 5.2 ± 0.89 at baseline to 0.9 ± 1.7 at study endpoint, p-value 
ISSN:0021-5155
1613-2246
DOI:10.1007/s10384-023-01016-4