Adult-onset chronic recurrent multifocal osteomyelitis: a case report

Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disease predominantly affecting the metaphyses of long bones and is usually seen in children. Although CRMO is generally a pediatric disease, it may also occur in adults. This may result in a delay in the diagnosis of adul...

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Bibliographic Details
Published in:Skeletal radiology 2024-02, Vol.53 (2), p.395-400
Main Authors: Yılmaz, Ebru, İncesoy, Mustafa Alper
Format: Article
Language:English
Subjects:
Adult
Antibiotics
Back pain
Biopsy
Bone and Bones
Bone diseases
Bone marrow
Bones
Case Report
Case reports
Child
Chronic Disease
Colchicine
Complaints
Complaints management
Diagnosis
Differential diagnosis
Edema
Female
Females
Health services
Humans
Imaging
Laboratories
Long bone
Magnetic resonance imaging
Medicine
Medicine & Public Health
Methotrexate
Microorganisms
Nonsteroidal anti-inflammatory drugs
Nuclear Medicine
Orthopedics
Osteomyelitis
Osteomyelitis - diagnostic imaging
Osteomyelitis - drug therapy
Outpatient care facilities
Pain
Pathology
Patients
Pediatrics
Prednisolone
Prednisolone - therapeutic use
Radiology
Remission
Scintigraphy
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Description
Summary:Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disease predominantly affecting the metaphyses of long bones and is usually seen in children. Although CRMO is generally a pediatric disease, it may also occur in adults. This may result in a delay in the diagnosis of adult-onset CRMO. This report presents an adult-onset female patient who presented with left leg pain followed by swelling in the right knee. The patient was initially started on colchicine treatment, but, due to unresponsiveness in the follow-up the patient, the treatment was switched to a combination of methotrexate and prednisolone. A satisfactory clinical recovery was achieved with these drugs. CRMO could be considered in the differential diagnosis of patients presenting with bone pain and joint complaints. Considering that the disease progresses with clinical flare-ups and remission periods, it should be kept in mind that patients should be followed closely and treatment can be changed.
ISSN:0364-2348
1432-2161
DOI:10.1007/s00256-023-04413-5