Nutrition support and clinical outcomes following allogeneic stem cell transplantation

Nutrition support is frequently required post allogeneic stem cell transplantation (SCT) and while there is some evidence on the benefits of enteral nutrition (EN), parenteral nutrition (PN) is widely used in practice. The study aimed to examine the impact of EN versus PN on early outcomes following...

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Bibliographic Details
Published in:Bone marrow transplantation (Basingstoke) 2023-10, Vol.58 (10), p.1137-1142
Main Authors: Andersen, Sarah, Xu, Jiani, Llewellyn, Stacey, Kennedy, Glen, Bauer, Judy
Format: Article
Language:English
Subjects:
692/699/67/1990
692/700/228
Allografts
Bone marrow
Cell Biology
Clinical outcomes
Enteral nutrition
Hematology
Internal Medicine
Leukocytes (neutrophilic)
Medicine
Medicine & Public Health
Nutrition
Parenteral nutrition
Patients
Public Health
Stem cell transplantation
Stem Cells
Transplantation
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Summary:Nutrition support is frequently required post allogeneic stem cell transplantation (SCT) and while there is some evidence on the benefits of enteral nutrition (EN), parenteral nutrition (PN) is widely used in practice. The study aimed to examine the impact of EN versus PN on early outcomes following SCT. All patients who underwent allogeneic SCT over 2.5 years were included in the analysis. Data was retrospectively collected on mode of nutrition support with clinical outcome data obtained from an existing database. Clinical outcomes were compared between groups by logistic, poisson and negative binomial regression, with adjustment for baseline confounders as appropriate. Patients who received EN then changed to PN had a longer length of hospital stay compared to those who received EN only (IR 1.24, 95% CI: 1.11–1.38, p  
ISSN:0268-3369
1476-5365
DOI:10.1038/s41409-023-02080-7