Resveratrol mitigates miR-212-3p mediated progression of diesel exhaust-induced pulmonary fibrosis by regulating SIRT1/FoxO3

Diesel exhaust (DE) exposure contributes to the progression of chronic respiratory diseases and is associated with dysregulation of microRNA expression. The present study aims to investigate the involvement of miRNAs and target genes in DE-induced lung fibrosis. C57BL/6 mice were divided into three...

Full description

Saved in:
Bibliographic Details
Published in:The Science of the total environment 2023-12, Vol.902, p.166063-166063, Article 166063
Main Authors: Singh, Naresh, Nagar, Ekta, Gautam, Anshu, Kapoor, Himanshi, Arora, Naveen
Format: Article
Language:English
Subjects:
Diesel exhaust
Lung fibrosis
Macrophage infiltration
miRNAs
Resveratrol
SIRT1
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Diesel exhaust (DE) exposure contributes to the progression of chronic respiratory diseases and is associated with dysregulation of microRNA expression. The present study aims to investigate the involvement of miRNAs and target genes in DE-induced lung fibrosis. C57BL/6 mice were divided into three groups. Group 1 mice were exposed to filtered air (Control). Group 2 mice were exposed to DE for 30 min per day, 5 days per week, for 8 weeks (DE). Group 3 mice received DE exposure along with resveratrol on alternate days for the last 2 weeks (DE + RES). Mice were sacrificed to isolate RNA from lung tissue for miRNA microarray profiling. Bronchoalveolar lavage fluid and lung tissues were collected for cell count and biochemical analysis. DE exposure resulted in differential expression of 28 miRNAs with fold change >2 (p 
ISSN:0048-9697
1879-1026
DOI:10.1016/j.scitotenv.2023.166063