Altitude-Related Venous Thrombosis With Heart Disease: An Updated Review

Altitude-related venous thrombosis (ARVT) is a condition of growing concern among individuals engaged in high-altitude travel and activities. This updated review explores the epidemiology, pathophysiological mechanisms, clinical presentations, and management of ARVT based on a thematic analysis and...

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Bibliographic Details
Published in:Current problems in cardiology 2024-01, Vol.49 (1 Pt A), p.102018-102018, Article 102018
Main Authors: Chaudhry, Waqar Arif Rasool, Ahmad, Binish Ayub, Waqas, Muhammad Saad, Khan, Junaid Raza, Khan, Malik Hasnat Ul Hassan, Khiyam, Umer, Malik, Jahanzeb
Format: Article
Language:English
Subjects:
Altitude
Anticoagulants - therapeutic use
Heart Diseases
Humans
Risk Factors
Venous Thromboembolism - etiology
Venous Thrombosis - epidemiology
Venous Thrombosis - etiology
Venous Thrombosis - prevention & control
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Summary:Altitude-related venous thrombosis (ARVT) is a condition of growing concern among individuals engaged in high-altitude travel and activities. This updated review explores the epidemiology, pathophysiological mechanisms, clinical presentations, and management of ARVT based on a thematic analysis and synthesis of the existing literature. ARVT's multifactorial etiology involves the interplay of hypobaric hypoxia and endothelial dysfunction, creating a procoagulant state and increasing the risk of thrombosis. Common clinical manifestations include pain, swelling, and redness in the extremities, necessitating accurate and timely diagnosis, particularly in remote settings. Thromboprophylaxis during high-altitude travel and activities plays a crucial role in reducing the risk of ARVT, while anticoagulation remains the mainstay of management. Further research is needed to optimize preventive and treatment strategies, enhancing patient outcomes and safety in high-altitude environments.
ISSN:0146-2806
1535-6280
DOI:10.1016/j.cpcardiol.2023.102018