Correlation of SV2C rs1423099 single nucleotide polymorphism with sporadic Parkinson's disease in Han population in Southern China

• Published in: Neuroscience letters 2023-09, Vol.813, p.137426-137426, Article 137426
• Main Authors: Tan, Zixin, Lin, Yuwan, Zhou, Miaomiao, Guo, Wenyuan, Qiu, Jiewen, Ding, Liuyan, Wu, Zhuohua, Xu, Pingyi, Chen, Xiang
• Format: Article
• Language: English
• Subjects: Parkinson’s disease; rs1423099; Single nucleotide polymorphism; SV2C
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/j.neulet.2023.137426

•The SV2C rs1423099 SNP was connected to sporadic PD in the Chinese Han population.•In allelic analysis, the C allele was found could increase the risk of PD.•In the male subgroup, those carrying the C allele had a greater probability of developing PD. The synaptic vesicle glycoprotein 2 (SV2) has been implicated in synaptic function throughout the brain. Accumulating evidence investigated that SV2C contributed to dopamine release and the disrupted expression of SV2C was considered to be a unique feature of PD that may facilitate dopaminergic neuron dysfunction. This study aimed to examine the relationship between the SV2C rs1423099 single nucleotide polymorphism and sporadic Parkinson's disease (PD) in the Chinese Han population. This study enrolled 351 patients with sporadic PD and 240 normal controls in Chinese Han population. Peripheral blood DNA was extracted by DNA extraction kits and the rs1423099 genotype was analyzed by Agena MassARRAY DNA mass spectrometry. The differences in genotype and allele distribution frequencies between PD patients and control groups were compared using chi-squared tests or Fisher's exact tests. No statistical difference was revealed in age and sex distribution between the cases and control groups, and the distribution of genotype and allele frequencies was consistent with the Hardy-Weinberg equilibrium test. In SV2C rs1423099 dominant model, the frequency of the CC/CT genotype was significantly higher in the PD group compared to the control group (OR = 4.065,95% CI: 2.801–10.870, p = 0.002). Nevertheless, in the recessive model, CC or CT/TT genotypes have no statistical difference in the two groups (p = 0.09). Additionally, in allelic analysis, the C allele was investigated to increase the risk of PD (OR = 1.346, 95% CI: 1.036–1.745, p = 0.026); Furthermore, subgroup analysis suggested that those carrying the C allele in the male subgroup were at a higher risk to afflicted with PD (OR = 1.637, 95% CI: 1.147–2.336, p = 0.006). SV2C rs1423099 single nucleotide polymorphism was associated with sporadic Parkinson's disease in the Chinese Han population, particularly in males.