Metal-phenolic capsules with ROS scavenging reshape the oxidative microenvironment of atherosclerosis

Arterial injury makes the tissue in a state of high oxidative stress. At the same time, abnormal lipid metabolism can further lead to bleeding and thrombosis. Therefore, the anti-inflammatory and anti-oxidant polyphenol, EGCG was organically complexed with Fe3+ to form a metal-phenolic framework car...

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Bibliographic Details
Published in:Nanomedicine 2023-09, Vol.53, p.102700-102700, Article 102700
Main Authors: Zhang, Aiai, Liu, Kaijing, Liang, Xiaoyu, Li, Huiyang, Fu, Xue, Zhu, Ni, Li, Fangjiang, Yang, Jing
Format: Article
Language:English
Subjects:
Anti-inflammation
Anti-oxidant
Atherosclerosis
Metal-phenolic framework
ROS scavenging
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Summary:Arterial injury makes the tissue in a state of high oxidative stress. At the same time, abnormal lipid metabolism can further lead to bleeding and thrombosis. Therefore, the anti-inflammatory and anti-oxidant polyphenol, EGCG was organically complexed with Fe3+ to form a metal-phenolic framework carrier. And the antihyperlipidemic drug, atorvastatin (ATV) was loaded into the carrier to enhance the bioavailability, and simultaneously alleviate the oxidative stress of the inflammatory site and abnormal lipid metabolism. The results confirmed that the obtained material EGCG-Fe-ATV had good biocompatibility and biosafety effect. In addition, EGCG-Fe-ATV showed outstanding anti-inflammatory, anti-oxidant and lipid-lowering properties. These therapeutic outcomes of EGCG-Fe-ATV were achieved by reducing systemic and local oxidative stress and inflammation, alleviating inflammatory cell infiltration in plaques, and modulating lipid synthesis and transferase to alter cholesterol transport. In conclusion, the combination of metal-phenolic capsules with ATV provides a new strategy for reshaping the oxidative microenvironment of atherosclerosis. 1.EGCG was complexed with Fe3+ to form a metal-phenolic framework carrier, which can effectively improve the inflammatory microenvironment of atherosclerosis.2.The antihyperlipidemic drug, atorvastatin (ATV) was loaded into the carrier to enhance the bioavailability, and simultaneously alleviate the oxidative stress of the inflammatory site and abnormal lipid metabolism.3.EGCG-Fe-ATV treatment resulted in less aortic plaque fat, more stable plaques, lower inflammatory macrophages and MCP-1. [Display omitted]
ISSN:1549-9634
1549-9642
DOI:10.1016/j.nano.2023.102700