Appraisal of anti-inflammatory and immunomodulatory potential of ramipril against Freund’s adjuvant-provoked arthritic rat model

Because of evident role of renin–angiotensin system in the etiology of rheumatoid arthritis, the current study’s objective was to assess the anti-arthritic efficacy of ramipril through CFA-instigated arthritic model. The drug has been shown to have anti-inflammatory potential. CFA-instigated arthrit...

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Bibliographic Details
Published in:Inflammopharmacology 2023-12, Vol.31 (6), p.3115-3125
Main Authors: Qasim, Sumera, Khan, Yusra Habib, Uttra, Ambreen Malik, Alotaibi, Nasser Hadal, Alanazi, Abdullah Salah, Alzarea, Abdulaziz I., Alatawi, Ahmed D., Mallhi, Tauqeer Hussain
Format: Article
Language:English
Subjects:
Allergology
Biomedical and Life Sciences
Biomedicine
Dermatology
Gastroenterology
Immunology
Original Article
Pharmacology/Toxicology
Rheumatology
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Summary:Because of evident role of renin–angiotensin system in the etiology of rheumatoid arthritis, the current study’s objective was to assess the anti-arthritic efficacy of ramipril through CFA-instigated arthritic model. The drug has been shown to have anti-inflammatory potential. CFA-instigated arthritic model assessed the anti-arthritic efficacy of ramipril by estimating different parameters, including paw volume, arthritic index scoring, haematological and biochemical attributes, histological and radiographic analyses, and various cytokines level. Ramipril significantly ( p < 0.001) reduced paw volume and the arthritic index especially at the dose of 4mg/kg. The biochemical and haematological changes were likewise restored to normal by ramipril administration with an increase in anti-inflammatory cytokines while reducing pro-inflammatory cytokines level. Ramipril’s ability to prevent arthritis by preserving the normal architecture of arthritis-induced joints is further supported by radiographic and histological investigation. The study’s findings demonstrated ramipril’s considerable anti-arthritic activity. To identify the precise mechanism of action, however, thorough mechanistic studies are still needed.
ISSN:0925-4692
1568-5608
DOI:10.1007/s10787-023-01306-w