Cancer chemoresistance and its mechanisms: Associated molecular factors and its regulatory role

Cancer therapy has advanced from tradition chemotherapy methods to targeted therapy, novel drug delivery mechanisms, combination therapies etc. Although several novel chemotherapy strategies have been introduced, chemoresistance still remains as one of the major barriers in cancer treatments. Chemor...

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Published in:Medical oncology (Northwood, London, England) London, England), 2023-08, Vol.40 (9), p.264-264, Article 264
Main Authors: Kannampuzha, Sandra, Gopalakrishnan, Abilash Valsala
Format: Article
Language:English
Subjects:
Apoptosis
Breast cancer
Cancer therapies
Chemotherapy
Drug delivery systems
Drug resistance
Efficiency
Hematology
Internal Medicine
Medicine
Medicine & Public Health
Metabolism
Metastasis
Mitochondria
Oncology
Ovarian cancer
Pathology
Patients
Review Article
Tumors
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Summary:Cancer therapy has advanced from tradition chemotherapy methods to targeted therapy, novel drug delivery mechanisms, combination therapies etc. Although several novel chemotherapy strategies have been introduced, chemoresistance still remains as one of the major barriers in cancer treatments. Chemoresistance can lead to relapse and hinder the development of improved clinical results for cancer patients, and this continues to be the major hurdle in cancer therapy. Anticancer drugs acquire chemoresistance through different mechanisms. Understanding these mechanisms is crucial to overcome and increase the efficiency of the cancer therapies that are employed. The potential molecular pathways behind chemoresistance include tumor heterogeneity, elevated drug efflux, multidrug resistance, interconnected signaling pathways, and other factors. To surpass this limitation, new clinical tactics are to be introduced. This review aims to compile the most recent information on the molecular pathways that regulate chemoresistance in cancers, which will aid in development of new therapeutic targets and strategies.
ISSN:1559-131X
1357-0560
1559-131X
DOI:10.1007/s12032-023-02138-y