Associations Between Atherosclerosis and Elevated Serum Alkaline Phosphatase in Patients With Coronary Artery Disease in an Inflammatory State

Serum alkaline phosphatase (ALP) has been shown to be associated with cardiovascular disease (CVD) risk. Inflammation is the initiator of atherosclerosis, throughout the life of atherosclerosis. This study investigated the relationship between serum ALP and atherosclerosis in patients with coronary...

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Bibliographic Details
Published in:Heart, lung & circulation lung & circulation, 2023-09, Vol.32 (9), p.1096-1106
Main Authors: Lai, Ziqin, Liu, Yijia, Huang, Mengnan, Li, Lin, Li, Zhu, Su, Jinyu, Pan, Guangwei, Li, Bin, Gao, Shan, Yu, Chunquan
Format: Article
Language:English
Subjects:
Alkaline phosphatase
Atherosclerosis
C-reactive protein
Cardiovascular disease
Inflammatory state
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Summary:Serum alkaline phosphatase (ALP) has been shown to be associated with cardiovascular disease (CVD) risk. Inflammation is the initiator of atherosclerosis, throughout the life of atherosclerosis. This study investigated the relationship between serum ALP and atherosclerosis in patients with coronary artery disease (CAD) in an inflammatory state. This was a multicentre retrospective study including 22,989 patients with CAD. Serum alkaline phosphatase was converted into the quartiles. C-reactive protein (CRP) was assayed as a marker of systemic inflammation. The atherosclerosis index (AI) was used to assess the degree of atherosclerosis. Binary logistic regression was used to analyse the relationship between ALP and AI. Stratified analysis was performed according to sex and age. Elevated serum ALP was associated with the risk of atherosclerosis in patients with CAD, and after quartiling ALP, the OR for Q4 was 1.17 (95% CI 1.08–1.26; p
ISSN:1443-9506
1444-2892
DOI:10.1016/j.hlc.2023.05.012