Serum neurofilament light chain is more strongly associated with T2 lesion volume than with number of T2 lesions in patients with multiple sclerosis

MR imaging provides information on the number and extend of focal lesions in multiple sclerosis (MS) patients. This study explores whether total brain T2 lesion volume or lesion number shows a better correlation with serum and cerebrospinal fluid (CSF) biomarkers of disease activity. In total, 52 pa...

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Published in:European journal of radiology 2023-09, Vol.166, p.111019-111019, Article 111019
Main Authors: Wenger, Katharina J, Hoelter, Maya C, Yalachkov, Yavor, Hendrik Schäfer, Jan, Özkan, Dilek, Steffen, Falk, Bittner, Stefan, Hattingen, Elke, Foerch, Christian, Schaller-Paule, Martin A
Format: Article
Language:English
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Summary:MR imaging provides information on the number and extend of focal lesions in multiple sclerosis (MS) patients. This study explores whether total brain T2 lesion volume or lesion number shows a better correlation with serum and cerebrospinal fluid (CSF) biomarkers of disease activity. In total, 52 patients suffering from clinically isolated syndrome (CIS)/relapsing-remitting multiple sclerosis (RRMS) were assessed including MRI markers (total brain T2 lesion volume semi-automatically outlined on 3D DIR/FLAIR sequences, number of lesions), serum and CSF biomarkers at the time of neuroimaging (neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP)), and clinical parameters. After log-transformation and partial correlations adjusted for the covariates patients' age, BMI, EDSS-score and diagnosis, the Fisher's r-to-Z transformation was used to compare different correlation coefficients. The correlation between lesion volume and serum NfL (r = 0.6, p 
ISSN:0720-048X
1872-7727
DOI:10.1016/j.ejrad.2023.111019