Cyclic Peptides from the Opportunistic Pathogen Basidiobolus meristosporus

Three new cyclic peptides, meristosporins A, B, and C (1–3), one of which features an unusual amino acid, were isolated from the opportunistic pathogen Basidiobolus meristosporus and identified by 1D, 2D NMR, MS/MS, and Marfey’s analysis. The biosynthetic pathway of the hexapeptide meristosporin A (...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2023-08, Vol.86 (8), p.1885-1890
Main Authors: Zhao, Cheng, Qu, Jiaojiao, Peng, Fan, Lu, Ruili, Bao, Guan-Hu, Huang, Bo, Hu, Fenglin
Format: Article
Language:English
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Summary:Three new cyclic peptides, meristosporins A, B, and C (1–3), one of which features an unusual amino acid, were isolated from the opportunistic pathogen Basidiobolus meristosporus and identified by 1D, 2D NMR, MS/MS, and Marfey’s analysis. The biosynthetic pathway of the hexapeptide meristosporin A (1) was deduced based on nonribosomal peptide synthetase gene clusters analysis. Compounds 1 and 2 showed cytotoxicity to RAW264.7 and 293T cells, respectively. These compounds may be involved in the fungal injury caused to human cells.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.2c01097