Loading…
Dietary intakes of total, nonheme, and heme iron and hypertension risk: a longitudinal study from the China Health and Nutrition Survey
Aims Evidence is limited regarding the long-term impact of dietary iron intake on the development of hypertension. We investigated the association between dietary intakes of total, nonheme, and heme iron and hypertension risk in a large prospective cohort of Chinese populations over 26 years. Method...
Saved in:
| Published in: | European journal of nutrition 2023-12, Vol.62 (8), p.3251-3262 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c375t-4bcda0b99065f2081deab7bad37d480f5aced24a855526d4c3634d0cfa17eeb53 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c375t-4bcda0b99065f2081deab7bad37d480f5aced24a855526d4c3634d0cfa17eeb53 |
| container_end_page | 3262 |
| container_issue | 8 |
| container_start_page | 3251 |
| container_title | European journal of nutrition |
| container_volume | 62 |
| creator | Wu, Shangling Chen, Peiyan He, Jingjing Liu, Zhaoyan Sui, Yi Li, Keji Fang, Aiping |
| description | Aims
Evidence is limited regarding the long-term impact of dietary iron intake on the development of hypertension. We investigated the association between dietary intakes of total, nonheme, and heme iron and hypertension risk in a large prospective cohort of Chinese populations over 26 years.
Methods
A total of 16,122 adults (7810 men and 8312 women) who participated in the China Health and Nutrition Survey (1989–2015) were included. Dietary intake was repeatedly assessed by combining three consecutive 24‑h individual dietary recalls with household food inventory weighing at each survey round. Incident hypertension was defined as systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg, diagnosis by physicians, or current use of anti-hypertensive drugs.
Results
During a median follow‑up of 11.1 years, 2863 men and 2532 women developed hypertension. After adjustment for non-dietary and dietary factors, a lower risk of hypertension was found in men and women with higher intakes of total, nonheme, or heme iron. The adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the highest vs. lowest quartiles were 0.76 (0.67, 0.87) in men and 0.85 (0.74, 0.97) in women for total iron intake, 0.77 (0.67, 0.87) in men and 0.85 (0.74, 0.98) in women for nonheme iron intake, and 0.73 (0.62, 0.87) in men and 0.69 (0.58, 0.82) in women for heme iron intake. Dose–response analyses further revealed a U-shaped association of total and nonheme iron intake and an L-shaped association of heme iron intake with hypertension risk in both men and women (all
P
for non-linearity |
| doi_str_mv | 10.1007/s00394-023-03230-9 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2848844547</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2848844547</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-4bcda0b99065f2081deab7bad37d480f5aced24a855526d4c3634d0cfa17eeb53</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhS0Eoj_wAiyQJTYsGpj4J3HYVZdCkSpYAGvLiSe9bhP7YjtI9wl4bXybUiQWrHw8_ubYnkPIixre1ADt2wTAO1EB4xVwxqHqHpHjWvCmalgtHz9oaI_ISUo3AAVt6qfkiLdSKtWpY_LrvcNs4p46n80tJhpGmkM20xn1wW9xxjNqvKUHRV0Mft3tdxgz-uRKIbp0-44aOgV_7fJinTcTTUXs6RjDTPMW6WZbqvQSzZS3dw6flxxdPrR_XeJP3D8jT0YzJXx-v56S7x8uvm0uq6svHz9tzq-qobw5V6IfrIG-66CRIwNVWzR92xvLWysUjNIMaJkwSkrJGisG3nBhYRhN3SL2kp-S16vvLoYfC6asZ5cGnCbjMSxJMyWUEkKKtqCv_kFvwhLL5w6UYg3IlWIrNcSQUsRR76Kby0R1DfoQk15j0mX2-i4m3ZWml_fWSz-jfWj5k0sB-AqkcuSvMf69-z-2vwG3zJ8O</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2882605547</pqid></control><display><type>article</type><title>Dietary intakes of total, nonheme, and heme iron and hypertension risk: a longitudinal study from the China Health and Nutrition Survey</title><source>Springer Nature</source><source>SPORTDiscus with Full Text</source><creator>Wu, Shangling ; Chen, Peiyan ; He, Jingjing ; Liu, Zhaoyan ; Sui, Yi ; Li, Keji ; Fang, Aiping</creator><creatorcontrib>Wu, Shangling ; Chen, Peiyan ; He, Jingjing ; Liu, Zhaoyan ; Sui, Yi ; Li, Keji ; Fang, Aiping</creatorcontrib><description>Aims
Evidence is limited regarding the long-term impact of dietary iron intake on the development of hypertension. We investigated the association between dietary intakes of total, nonheme, and heme iron and hypertension risk in a large prospective cohort of Chinese populations over 26 years.
Methods
A total of 16,122 adults (7810 men and 8312 women) who participated in the China Health and Nutrition Survey (1989–2015) were included. Dietary intake was repeatedly assessed by combining three consecutive 24‑h individual dietary recalls with household food inventory weighing at each survey round. Incident hypertension was defined as systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg, diagnosis by physicians, or current use of anti-hypertensive drugs.
Results
During a median follow‑up of 11.1 years, 2863 men and 2532 women developed hypertension. After adjustment for non-dietary and dietary factors, a lower risk of hypertension was found in men and women with higher intakes of total, nonheme, or heme iron. The adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the highest vs. lowest quartiles were 0.76 (0.67, 0.87) in men and 0.85 (0.74, 0.97) in women for total iron intake, 0.77 (0.67, 0.87) in men and 0.85 (0.74, 0.98) in women for nonheme iron intake, and 0.73 (0.62, 0.87) in men and 0.69 (0.58, 0.82) in women for heme iron intake. Dose–response analyses further revealed a U-shaped association of total and nonheme iron intake and an L-shaped association of heme iron intake with hypertension risk in both men and women (all
P
for non-linearity < 0.001).
Conclusions
Our findings emphasize the importance of maintaining moderate iron intake in the prevention of hypertension. Both insufficient and excess intake of iron might increase the risk of hypertension.</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-023-03230-9</identifier><identifier>PMID: 37558898</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Antihypertensives ; Blood pressure ; Chemistry ; Chemistry and Materials Science ; Cohort analysis ; Diet ; Dietary intake ; Heme ; Hypertension ; Iron ; Longitudinal studies ; Nutrition ; Original Contribution ; Surveys ; Women</subject><ispartof>European journal of nutrition, 2023-12, Vol.62 (8), p.3251-3262</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-4bcda0b99065f2081deab7bad37d480f5aced24a855526d4c3634d0cfa17eeb53</citedby><cites>FETCH-LOGICAL-c375t-4bcda0b99065f2081deab7bad37d480f5aced24a855526d4c3634d0cfa17eeb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37558898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Shangling</creatorcontrib><creatorcontrib>Chen, Peiyan</creatorcontrib><creatorcontrib>He, Jingjing</creatorcontrib><creatorcontrib>Liu, Zhaoyan</creatorcontrib><creatorcontrib>Sui, Yi</creatorcontrib><creatorcontrib>Li, Keji</creatorcontrib><creatorcontrib>Fang, Aiping</creatorcontrib><title>Dietary intakes of total, nonheme, and heme iron and hypertension risk: a longitudinal study from the China Health and Nutrition Survey</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>Aims
Evidence is limited regarding the long-term impact of dietary iron intake on the development of hypertension. We investigated the association between dietary intakes of total, nonheme, and heme iron and hypertension risk in a large prospective cohort of Chinese populations over 26 years.
Methods
A total of 16,122 adults (7810 men and 8312 women) who participated in the China Health and Nutrition Survey (1989–2015) were included. Dietary intake was repeatedly assessed by combining three consecutive 24‑h individual dietary recalls with household food inventory weighing at each survey round. Incident hypertension was defined as systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg, diagnosis by physicians, or current use of anti-hypertensive drugs.
Results
During a median follow‑up of 11.1 years, 2863 men and 2532 women developed hypertension. After adjustment for non-dietary and dietary factors, a lower risk of hypertension was found in men and women with higher intakes of total, nonheme, or heme iron. The adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the highest vs. lowest quartiles were 0.76 (0.67, 0.87) in men and 0.85 (0.74, 0.97) in women for total iron intake, 0.77 (0.67, 0.87) in men and 0.85 (0.74, 0.98) in women for nonheme iron intake, and 0.73 (0.62, 0.87) in men and 0.69 (0.58, 0.82) in women for heme iron intake. Dose–response analyses further revealed a U-shaped association of total and nonheme iron intake and an L-shaped association of heme iron intake with hypertension risk in both men and women (all
P
for non-linearity < 0.001).
Conclusions
Our findings emphasize the importance of maintaining moderate iron intake in the prevention of hypertension. Both insufficient and excess intake of iron might increase the risk of hypertension.</description><subject>Antihypertensives</subject><subject>Blood pressure</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Cohort analysis</subject><subject>Diet</subject><subject>Dietary intake</subject><subject>Heme</subject><subject>Hypertension</subject><subject>Iron</subject><subject>Longitudinal studies</subject><subject>Nutrition</subject><subject>Original Contribution</subject><subject>Surveys</subject><subject>Women</subject><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1TAQhS0Eoj_wAiyQJTYsGpj4J3HYVZdCkSpYAGvLiSe9bhP7YjtI9wl4bXybUiQWrHw8_ubYnkPIixre1ADt2wTAO1EB4xVwxqHqHpHjWvCmalgtHz9oaI_ISUo3AAVt6qfkiLdSKtWpY_LrvcNs4p46n80tJhpGmkM20xn1wW9xxjNqvKUHRV0Mft3tdxgz-uRKIbp0-44aOgV_7fJinTcTTUXs6RjDTPMW6WZbqvQSzZS3dw6flxxdPrR_XeJP3D8jT0YzJXx-v56S7x8uvm0uq6svHz9tzq-qobw5V6IfrIG-66CRIwNVWzR92xvLWysUjNIMaJkwSkrJGisG3nBhYRhN3SL2kp-S16vvLoYfC6asZ5cGnCbjMSxJMyWUEkKKtqCv_kFvwhLL5w6UYg3IlWIrNcSQUsRR76Kby0R1DfoQk15j0mX2-i4m3ZWml_fWSz-jfWj5k0sB-AqkcuSvMf69-z-2vwG3zJ8O</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Wu, Shangling</creator><creator>Chen, Peiyan</creator><creator>He, Jingjing</creator><creator>Liu, Zhaoyan</creator><creator>Sui, Yi</creator><creator>Li, Keji</creator><creator>Fang, Aiping</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20231201</creationdate><title>Dietary intakes of total, nonheme, and heme iron and hypertension risk: a longitudinal study from the China Health and Nutrition Survey</title><author>Wu, Shangling ; Chen, Peiyan ; He, Jingjing ; Liu, Zhaoyan ; Sui, Yi ; Li, Keji ; Fang, Aiping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-4bcda0b99065f2081deab7bad37d480f5aced24a855526d4c3634d0cfa17eeb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antihypertensives</topic><topic>Blood pressure</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Cohort analysis</topic><topic>Diet</topic><topic>Dietary intake</topic><topic>Heme</topic><topic>Hypertension</topic><topic>Iron</topic><topic>Longitudinal studies</topic><topic>Nutrition</topic><topic>Original Contribution</topic><topic>Surveys</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Shangling</creatorcontrib><creatorcontrib>Chen, Peiyan</creatorcontrib><creatorcontrib>He, Jingjing</creatorcontrib><creatorcontrib>Liu, Zhaoyan</creatorcontrib><creatorcontrib>Sui, Yi</creatorcontrib><creatorcontrib>Li, Keji</creatorcontrib><creatorcontrib>Fang, Aiping</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Shangling</au><au>Chen, Peiyan</au><au>He, Jingjing</au><au>Liu, Zhaoyan</au><au>Sui, Yi</au><au>Li, Keji</au><au>Fang, Aiping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary intakes of total, nonheme, and heme iron and hypertension risk: a longitudinal study from the China Health and Nutrition Survey</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><addtitle>Eur J Nutr</addtitle><date>2023-12-01</date><risdate>2023</risdate><volume>62</volume><issue>8</issue><spage>3251</spage><epage>3262</epage><pages>3251-3262</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>Aims
Evidence is limited regarding the long-term impact of dietary iron intake on the development of hypertension. We investigated the association between dietary intakes of total, nonheme, and heme iron and hypertension risk in a large prospective cohort of Chinese populations over 26 years.
Methods
A total of 16,122 adults (7810 men and 8312 women) who participated in the China Health and Nutrition Survey (1989–2015) were included. Dietary intake was repeatedly assessed by combining three consecutive 24‑h individual dietary recalls with household food inventory weighing at each survey round. Incident hypertension was defined as systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg, diagnosis by physicians, or current use of anti-hypertensive drugs.
Results
During a median follow‑up of 11.1 years, 2863 men and 2532 women developed hypertension. After adjustment for non-dietary and dietary factors, a lower risk of hypertension was found in men and women with higher intakes of total, nonheme, or heme iron. The adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the highest vs. lowest quartiles were 0.76 (0.67, 0.87) in men and 0.85 (0.74, 0.97) in women for total iron intake, 0.77 (0.67, 0.87) in men and 0.85 (0.74, 0.98) in women for nonheme iron intake, and 0.73 (0.62, 0.87) in men and 0.69 (0.58, 0.82) in women for heme iron intake. Dose–response analyses further revealed a U-shaped association of total and nonheme iron intake and an L-shaped association of heme iron intake with hypertension risk in both men and women (all
P
for non-linearity < 0.001).
Conclusions
Our findings emphasize the importance of maintaining moderate iron intake in the prevention of hypertension. Both insufficient and excess intake of iron might increase the risk of hypertension.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37558898</pmid><doi>10.1007/s00394-023-03230-9</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1436-6207 |
| ispartof | European journal of nutrition, 2023-12, Vol.62 (8), p.3251-3262 |
| issn | 1436-6207 1436-6215 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2848844547 |
| source | Springer Nature; SPORTDiscus with Full Text |
| subjects | Antihypertensives Blood pressure Chemistry Chemistry and Materials Science Cohort analysis Diet Dietary intake Heme Hypertension Iron Longitudinal studies Nutrition Original Contribution Surveys Women |
| title | Dietary intakes of total, nonheme, and heme iron and hypertension risk: a longitudinal study from the China Health and Nutrition Survey |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T05%3A31%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dietary%20intakes%20of%20total,%20nonheme,%20and%20heme%20iron%20and%20hypertension%20risk:%20a%20longitudinal%20study%20from%20the%20China%20Health%20and%20Nutrition%20Survey&rft.jtitle=European%20journal%20of%20nutrition&rft.au=Wu,%20Shangling&rft.date=2023-12-01&rft.volume=62&rft.issue=8&rft.spage=3251&rft.epage=3262&rft.pages=3251-3262&rft.issn=1436-6207&rft.eissn=1436-6215&rft_id=info:doi/10.1007/s00394-023-03230-9&rft_dat=%3Cproquest_cross%3E2848844547%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c375t-4bcda0b99065f2081deab7bad37d480f5aced24a855526d4c3634d0cfa17eeb53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2882605547&rft_id=info:pmid/37558898&rfr_iscdi=true |