When in doubt, return to fundamentals (seizure semiology)

This case of drug resistant focal epilepsy highlights several invaluable teaching points. Hypotheses grounded in seizure semiology provide the best framework to ensure accurate interpretation of diagnostic testing. Without a hypothesis, information gathered from tests can be difficult to linearly pi...

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Bibliographic Details
Published in:Epileptic disorders 2023-10, Vol.25 (5), p.769-778
Main Authors: Nordli, 3rd, Douglas R, Beier, Alexandra D, Galan, Fernando N
Format: Article
Language:English
Subjects:
Drug resistance
Epilepsy
Quality of life
Seizures
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Summary:This case of drug resistant focal epilepsy highlights several invaluable teaching points. Hypotheses grounded in seizure semiology provide the best framework to ensure accurate interpretation of diagnostic testing. Without a hypothesis, information gathered from tests can be difficult to linearly piece together and can lead to poor patient outcomes. The case also provides a real-world conundrum of discordant test results that were ultimately rectified by re-visiting the initial hypothesis and cross-testing. Perinatal stroke continues to be a common etiology of drug resistant epilepsy. Patients can achieve seizure freedom and good quality of life with appropriate workup and in appropriate cases, surgery.
ISSN:1294-9361
1950-6945
DOI:10.1002/epd2.20140