Occurrence and conversion of progestogens and androgens are conserved in land plants

Progestogens and androgens have been found in many plants, but little is known about their biosynthesis and the evolution of steroidogenesis in these organisms. Here, we show that the occurrence and biosynthesis of progestogens and androgens are conserved across the viridiplantae lineage. An UHPLC-E...

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Published in:The New phytologist 2023-10, Vol.240 (1), p.318-337
Main Authors: Shiko, Glendis, Paulmann, Max-Jonas, Feistel, Felix, Ntefidou, Maria, Hermann-Ene, Vanessa, Vetter, Walter, Kost, Benedikt, Kunert, Grit, Zedler, Julie A Z, Reichelt, Michael, Oelmüller, Ralf, Klein, Jan
Format: Article
Language:English
Subjects:
Androgens
Biosynthesis
Conversion
Dehydroepiandrosterone
Dihydrotestosterone
Lyases
Plants
Sex hormones
Steroid hormones
Steroidogenesis
Testosterone
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container_end_page 337
container_issue 1
container_start_page 318
container_title The New phytologist
container_volume 240
creator Shiko, Glendis
Paulmann, Max-Jonas
Feistel, Felix
Ntefidou, Maria
Hermann-Ene, Vanessa
Vetter, Walter
Kost, Benedikt
Kunert, Grit
Zedler, Julie A Z
Reichelt, Michael
Oelmüller, Ralf
Klein, Jan
description Progestogens and androgens have been found in many plants, but little is known about their biosynthesis and the evolution of steroidogenesis in these organisms. Here, we show that the occurrence and biosynthesis of progestogens and androgens are conserved across the viridiplantae lineage. An UHPLC-ESI-MS/MS method allowed high-throughput analysis of the occurrence and chemical conversion of progestogens and androgens in 41 species across the green plant lineage. Dehydroepiandrosterone, testosterone, and 5α-dihydrotestosterone are plants' most abundant mammalian-like steroids. Progestogens are converted into 17α-hydroxyprogesterone and 5α-pregnane-3,20-dione. Androgens are converted into testosterone and 5α-dihydrotestosterone. 17,20-Lyases, essential for converting progestogens to androgens, seem to be most effective in monocot species. Our data suggest that the occurrence of progestogens and androgens is highly conserved in plants, and their biosynthesis might favor a route using the Δ pathway.
doi_str_mv 10.1111/nph.19163
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subjects Androgens
Biosynthesis
Conversion
Dehydroepiandrosterone
Dihydrotestosterone
Lyases
Plants
Sex hormones
Steroid hormones
Steroidogenesis
Testosterone
title Occurrence and conversion of progestogens and androgens are conserved in land plants
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