DNA damage as an early biomarker of effect in human health

In the last few decades the need for new approaches to assess DNA damage has been increasing due to the implications that different insults on genetic material may have on human health. In this context, the identification of how chemical agents with different mechanisms of action (i.e., antineoplast...

Full description

Saved in:
Bibliographic Details
Published in:Toxicology and industrial health 2005-09, Vol.21 (5-6), p.155-166
Main Authors: Mussali-Galante, P, Avila-Costa, MR, Piñón-Zarate, G, Martínez-Levy, G, Rodríguez-Lara, V, Rojas-Lemus, M, Avila-Casado, MC, Fortoul, TI
Format: Article
Language:English
Subjects:
Antineoplastic Agents - adverse effects
Antineoplastic drugs
Biological
Biomarkers
Comet Assay - methods
Deoxyribonucleic acid
DNA Damage
Drugs
Electrophoresis - methods
Female
Genetics
Health
Human
Humans
Male
Nasal Mucosa - drug effects
Pollutants
Toxicology
Xenobiotics - adverse effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c427t-43ca891cb3d95872aaec26fd367597c7538cf36217b661e666af792f6d45f85c3
cites cdi_FETCH-LOGICAL-c427t-43ca891cb3d95872aaec26fd367597c7538cf36217b661e666af792f6d45f85c3
container_end_page 166
container_issue 5-6
container_start_page 155
container_title Toxicology and industrial health
container_volume 21
creator Mussali-Galante, P
Avila-Costa, MR
Piñón-Zarate, G
Martínez-Levy, G
Rodríguez-Lara, V
Rojas-Lemus, M
Avila-Casado, MC
Fortoul, TI
description In the last few decades the need for new approaches to assess DNA damage has been increasing due to the implications that different insults on genetic material may have on human health. In this context, the identification of how chemical agents with different mechanisms of action (i.e., antineoplastic drugs) damage DNA provides a good model to investigate some cellular and molecular mechanisms underlying the basis of genetic toxicology. The nasal epithelium is the first barrier with which environmental pollutants interact, and for this reason this epithelium can be useful as a sentinel in order to assess the interactions between the environment and the living organisms. Taking these phenomena into account and using a simple, sensitive and rapid method such as the single cell gel electrophoresis, we could obtain information and an initial approach on the DNA status. This assay in combination with other techniques that provide more information about other molecular parameters could give us a better view of the biological status of the living cell.
doi_str_mv 10.1191/0748233705th224oa
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_28494601</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1191_0748233705th224oa</sage_id><sourcerecordid>869092111</sourcerecordid><originalsourceid>FETCH-LOGICAL-c427t-43ca891cb3d95872aaec26fd367597c7538cf36217b661e666af792f6d45f85c3</originalsourceid><addsrcrecordid>eNqFkLtOwzAUhi0EoqXwACzIYmBL8d0xW9VykypYYI4cxyYpuRQ7Gfr2uGqlSiDEdIbz_f_R-QC4xGiKscK3SLKUUCoR70tCWKePwBgzKRNEFT0G4-0-2QIjcBbCCiEkBCenYIQFZkpSNAZ3i5cZLHSjPyzUAeoWWu3rDcyrrtH-03rYOWids6aHVQvLoYlIaXXdl-fgxOk62Iv9nID3h_u3-VOyfH18ns-WiWFE9gmjRqcKm5wWiqeSaG0NEa6gQnIljeQ0NY4KgmUuBLZCCO2kIk4UjLuUGzoBN7vete--Bhv6rKmCsXWtW9sNISMpU0wg_C-IBUFSShLB6x_gqht8G5_ICKFEIc7SCOEdZHwXgrcuW_sqOtlkGGVb_dkv_TFztS8e8sYWh8TedwSmOyBE4Yerfzd-A7vzi8A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223290548</pqid></control><display><type>article</type><title>DNA damage as an early biomarker of effect in human health</title><source>Sage Journals Online</source><creator>Mussali-Galante, P ; Avila-Costa, MR ; Piñón-Zarate, G ; Martínez-Levy, G ; Rodríguez-Lara, V ; Rojas-Lemus, M ; Avila-Casado, MC ; Fortoul, TI</creator><creatorcontrib>Mussali-Galante, P ; Avila-Costa, MR ; Piñón-Zarate, G ; Martínez-Levy, G ; Rodríguez-Lara, V ; Rojas-Lemus, M ; Avila-Casado, MC ; Fortoul, TI</creatorcontrib><description>In the last few decades the need for new approaches to assess DNA damage has been increasing due to the implications that different insults on genetic material may have on human health. In this context, the identification of how chemical agents with different mechanisms of action (i.e., antineoplastic drugs) damage DNA provides a good model to investigate some cellular and molecular mechanisms underlying the basis of genetic toxicology. The nasal epithelium is the first barrier with which environmental pollutants interact, and for this reason this epithelium can be useful as a sentinel in order to assess the interactions between the environment and the living organisms. Taking these phenomena into account and using a simple, sensitive and rapid method such as the single cell gel electrophoresis, we could obtain information and an initial approach on the DNA status. This assay in combination with other techniques that provide more information about other molecular parameters could give us a better view of the biological status of the living cell.</description><identifier>ISSN: 0748-2337</identifier><identifier>EISSN: 1477-0393</identifier><identifier>DOI: 10.1191/0748233705th224oa</identifier><identifier>PMID: 16149730</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Antineoplastic Agents - adverse effects ; Antineoplastic drugs ; Biological ; Biomarkers ; Comet Assay - methods ; Deoxyribonucleic acid ; DNA Damage ; Drugs ; Electrophoresis - methods ; Female ; Genetics ; Health ; Human ; Humans ; Male ; Nasal Mucosa - drug effects ; Pollutants ; Toxicology ; Xenobiotics - adverse effects</subject><ispartof>Toxicology and industrial health, 2005-09, Vol.21 (5-6), p.155-166</ispartof><rights>2005 Arnold</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-43ca891cb3d95872aaec26fd367597c7538cf36217b661e666af792f6d45f85c3</citedby><cites>FETCH-LOGICAL-c427t-43ca891cb3d95872aaec26fd367597c7538cf36217b661e666af792f6d45f85c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,79364</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16149730$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mussali-Galante, P</creatorcontrib><creatorcontrib>Avila-Costa, MR</creatorcontrib><creatorcontrib>Piñón-Zarate, G</creatorcontrib><creatorcontrib>Martínez-Levy, G</creatorcontrib><creatorcontrib>Rodríguez-Lara, V</creatorcontrib><creatorcontrib>Rojas-Lemus, M</creatorcontrib><creatorcontrib>Avila-Casado, MC</creatorcontrib><creatorcontrib>Fortoul, TI</creatorcontrib><title>DNA damage as an early biomarker of effect in human health</title><title>Toxicology and industrial health</title><addtitle>Toxicol Ind Health</addtitle><description>In the last few decades the need for new approaches to assess DNA damage has been increasing due to the implications that different insults on genetic material may have on human health. In this context, the identification of how chemical agents with different mechanisms of action (i.e., antineoplastic drugs) damage DNA provides a good model to investigate some cellular and molecular mechanisms underlying the basis of genetic toxicology. The nasal epithelium is the first barrier with which environmental pollutants interact, and for this reason this epithelium can be useful as a sentinel in order to assess the interactions between the environment and the living organisms. Taking these phenomena into account and using a simple, sensitive and rapid method such as the single cell gel electrophoresis, we could obtain information and an initial approach on the DNA status. This assay in combination with other techniques that provide more information about other molecular parameters could give us a better view of the biological status of the living cell.</description><subject>Antineoplastic Agents - adverse effects</subject><subject>Antineoplastic drugs</subject><subject>Biological</subject><subject>Biomarkers</subject><subject>Comet Assay - methods</subject><subject>Deoxyribonucleic acid</subject><subject>DNA Damage</subject><subject>Drugs</subject><subject>Electrophoresis - methods</subject><subject>Female</subject><subject>Genetics</subject><subject>Health</subject><subject>Human</subject><subject>Humans</subject><subject>Male</subject><subject>Nasal Mucosa - drug effects</subject><subject>Pollutants</subject><subject>Toxicology</subject><subject>Xenobiotics - adverse effects</subject><issn>0748-2337</issn><issn>1477-0393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqFkLtOwzAUhi0EoqXwACzIYmBL8d0xW9VykypYYI4cxyYpuRQ7Gfr2uGqlSiDEdIbz_f_R-QC4xGiKscK3SLKUUCoR70tCWKePwBgzKRNEFT0G4-0-2QIjcBbCCiEkBCenYIQFZkpSNAZ3i5cZLHSjPyzUAeoWWu3rDcyrrtH-03rYOWids6aHVQvLoYlIaXXdl-fgxOk62Iv9nID3h_u3-VOyfH18ns-WiWFE9gmjRqcKm5wWiqeSaG0NEa6gQnIljeQ0NY4KgmUuBLZCCO2kIk4UjLuUGzoBN7vete--Bhv6rKmCsXWtW9sNISMpU0wg_C-IBUFSShLB6x_gqht8G5_ICKFEIc7SCOEdZHwXgrcuW_sqOtlkGGVb_dkv_TFztS8e8sYWh8TedwSmOyBE4Yerfzd-A7vzi8A</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>Mussali-Galante, P</creator><creator>Avila-Costa, MR</creator><creator>Piñón-Zarate, G</creator><creator>Martínez-Levy, G</creator><creator>Rodríguez-Lara, V</creator><creator>Rojas-Lemus, M</creator><creator>Avila-Casado, MC</creator><creator>Fortoul, TI</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QF</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T2</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8BQ</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>H8G</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>7TM</scope><scope>7TV</scope><scope>7U2</scope><scope>7SU</scope></search><sort><creationdate>20050901</creationdate><title>DNA damage as an early biomarker of effect in human health</title><author>Mussali-Galante, P ; Avila-Costa, MR ; Piñón-Zarate, G ; Martínez-Levy, G ; Rodríguez-Lara, V ; Rojas-Lemus, M ; Avila-Casado, MC ; Fortoul, TI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-43ca891cb3d95872aaec26fd367597c7538cf36217b661e666af792f6d45f85c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Antineoplastic Agents - adverse effects</topic><topic>Antineoplastic drugs</topic><topic>Biological</topic><topic>Biomarkers</topic><topic>Comet Assay - methods</topic><topic>Deoxyribonucleic acid</topic><topic>DNA Damage</topic><topic>Drugs</topic><topic>Electrophoresis - methods</topic><topic>Female</topic><topic>Genetics</topic><topic>Health</topic><topic>Human</topic><topic>Humans</topic><topic>Male</topic><topic>Nasal Mucosa - drug effects</topic><topic>Pollutants</topic><topic>Toxicology</topic><topic>Xenobiotics - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mussali-Galante, P</creatorcontrib><creatorcontrib>Avila-Costa, MR</creatorcontrib><creatorcontrib>Piñón-Zarate, G</creatorcontrib><creatorcontrib>Martínez-Levy, G</creatorcontrib><creatorcontrib>Rodríguez-Lara, V</creatorcontrib><creatorcontrib>Rojas-Lemus, M</creatorcontrib><creatorcontrib>Avila-Casado, MC</creatorcontrib><creatorcontrib>Fortoul, TI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics &amp; Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Materials Business File</collection><collection>Mechanical &amp; Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>ProQuest_Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>METADEX</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ANTE: Abstracts in New Technology &amp; Engineering</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>ProQuest Engineering Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts – Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Engineering Database</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Nucleic Acids Abstracts</collection><collection>Pollution Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Engineering Abstracts</collection><jtitle>Toxicology and industrial health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mussali-Galante, P</au><au>Avila-Costa, MR</au><au>Piñón-Zarate, G</au><au>Martínez-Levy, G</au><au>Rodríguez-Lara, V</au><au>Rojas-Lemus, M</au><au>Avila-Casado, MC</au><au>Fortoul, TI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DNA damage as an early biomarker of effect in human health</atitle><jtitle>Toxicology and industrial health</jtitle><addtitle>Toxicol Ind Health</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>21</volume><issue>5-6</issue><spage>155</spage><epage>166</epage><pages>155-166</pages><issn>0748-2337</issn><eissn>1477-0393</eissn><abstract>In the last few decades the need for new approaches to assess DNA damage has been increasing due to the implications that different insults on genetic material may have on human health. In this context, the identification of how chemical agents with different mechanisms of action (i.e., antineoplastic drugs) damage DNA provides a good model to investigate some cellular and molecular mechanisms underlying the basis of genetic toxicology. The nasal epithelium is the first barrier with which environmental pollutants interact, and for this reason this epithelium can be useful as a sentinel in order to assess the interactions between the environment and the living organisms. Taking these phenomena into account and using a simple, sensitive and rapid method such as the single cell gel electrophoresis, we could obtain information and an initial approach on the DNA status. This assay in combination with other techniques that provide more information about other molecular parameters could give us a better view of the biological status of the living cell.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>16149730</pmid><doi>10.1191/0748233705th224oa</doi><tpages>12</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0748-2337
ispartof Toxicology and industrial health, 2005-09, Vol.21 (5-6), p.155-166
issn 0748-2337
1477-0393
language eng
recordid cdi_proquest_miscellaneous_28494601
source Sage Journals Online
subjects Antineoplastic Agents - adverse effects
Antineoplastic drugs
Biological
Biomarkers
Comet Assay - methods
Deoxyribonucleic acid
DNA Damage
Drugs
Electrophoresis - methods
Female
Genetics
Health
Human
Humans
Male
Nasal Mucosa - drug effects
Pollutants
Toxicology
Xenobiotics - adverse effects
title DNA damage as an early biomarker of effect in human health
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T10%3A46%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=DNA%20damage%20as%20an%20early%20biomarker%20of%20effect%20in%20human%20health&rft.jtitle=Toxicology%20and%20industrial%20health&rft.au=Mussali-Galante,%20P&rft.date=2005-09-01&rft.volume=21&rft.issue=5-6&rft.spage=155&rft.epage=166&rft.pages=155-166&rft.issn=0748-2337&rft.eissn=1477-0393&rft_id=info:doi/10.1191/0748233705th224oa&rft_dat=%3Cproquest_cross%3E869092111%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c427t-43ca891cb3d95872aaec26fd367597c7538cf36217b661e666af792f6d45f85c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=223290548&rft_id=info:pmid/16149730&rft_sage_id=10.1191_0748233705th224oa&rfr_iscdi=true