The importance, prevalence and determination of vitamins B6 and B12 in food matrices: A review

•Vitamins B6 and B12 are essential to daily human physiological functions.•Vitamins B6 and B12 deficiencies lead to prominent and prevalent health conditions.•B6 is found in starchy foods, whereas B12 is accumulated throughout the food chain.•Despite the multitude of methods of determination, HPLC r...

Full description

Saved in:
Bibliographic Details
Published in:Food chemistry 2023-11, Vol.426, p.136606-136606, Article 136606
Main Authors: Santos, A.J.M., Khemiri, S., Simões, S., Prista, C., Sousa, I., Raymundo, A.
Format: Article
Language:English
Subjects:
chromatography
Cobalamin
cobalt
fatty acids
food chemistry
growth and development
human physiology
humans
hydrophilicity
organometallic compounds
prokaryotic cells
Pyridoxal
Pyridoxamine
Pyridoxine
sugars
Vitamin B12
Vitamin B6
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Vitamins B6 and B12 are essential to daily human physiological functions.•Vitamins B6 and B12 deficiencies lead to prominent and prevalent health conditions.•B6 is found in starchy foods, whereas B12 is accumulated throughout the food chain.•Despite the multitude of methods of determination, HPLC remains the most accurate. Vitamins are a vast group of fundamental organic compounds, which are not produced by the human body but are essential for the living organisms’ good health. Vitamins B6 and B12 belong to the same group of hydrophilic vitamins. Structurally unrelated, they share the same purpose as essential components for normal cellular operation, growth and development. Vitamin B6 is an enzymatic co-factor that is vital for countless biochemical reactions, and is also important in sugar and fatty acid metabolization. It encompasses three natural and inter-convertible pyridine-derivatives: pyridoxine, pyridoxal and pyridoxamine. Vitamin B12 is a cobalt organometallic complex also indispensable in numerous human physiological functions. It has four bioactive forms: cyanocobalamin, methylcobalamin, hydroxocobalamin and 5′-deoxyadenosylcobalamin, and only a few prokaryotes have the ability to biosynthesize cobalamin. This work reviews the significant aspects of vitamins B6 and B12: their vital roles, consequences of deficit; food sources; and methods of determination and respective matrices, with heavy emphasis on chromatographic techniques developed within the last two decades.
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2023.136606