Omega 6/Omega 3 Ratio Is High in Individuals with Increased Sperm DNA fragmentation

An imbalance between omega-6 and omega-3 fatty acids in sperm has been linked with lipid peroxidation and DNA damage in sperm, indicating a possible correlation to fertility potential. This cross-sectional study involved 56 infertile men (aged 25–45), and assessed the relationship between the omega-...

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Bibliographic Details
Published in:Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2023-12, Vol.30 (12), p.3469-3479
Main Authors: Abdollahzadeh, Saeideh, Riasi, Ahmad, Tavalaee, Marziyeh, Jafarpour, Farnoosh, Nasr‐Esfahani, M. H.
Format: Article
Language:English
Subjects:
Cross-Sectional Studies
DNA Fragmentation
Embryology
Fatty Acids, Omega-3
Humans
Infertility, Male
Male
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Reproductive Biology: Original Article
Reproductive Medicine
Semen
Sperm Motility
Spermatozoa
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Summary:An imbalance between omega-6 and omega-3 fatty acids in sperm has been linked with lipid peroxidation and DNA damage in sperm, indicating a possible correlation to fertility potential. This cross-sectional study involved 56 infertile men (aged 25–45), and assessed the relationship between the omega-6 to omega-3 fatty acid ratio in sperm and seminal plasma with sperm DNA fragmentation. Individuals were categorized based on high or low levels of sperm DNA fragmentation according to two tests (TUNEL and SCSA assay less or greater than 10 and 30%, respectively), and their fatty acid composition, as well as sperm functional tests, were analyzed. Results showed that men with high DNA fragmentation exhibited higher percentages of total saturated, monounsaturated, and omega-6 to omega-3 fatty acid ratios in both sperm ( P  
ISSN:1933-7191
1933-7205
DOI:10.1007/s43032-023-01313-w