In Vivo Application of Magnetic Molecularly Imprinted Polymer in Rheumatoid Arthritis Rat Model

A magnetic molecularly imprinted polymer (MMIP) was synthesized and tested for an rheumatoid arthritis (RA) rat model. Magnetite coated with mesoporous silica (Fe O @mSi) was used as core for surface imprinting, dopamine was used as monomer and methotrexate (MTX) was loaded directly during polymeriz...

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Bibliographic Details
Published in:Journal of drug targeting 2023-09, Vol.31 (8), p.1-888
Main Authors: Soliman, Mariam, Shanan, Nagwan, Eissa, Gamal, Mizaikoff, Boris, El Gohary, Nesrine A
Format: Article
Language:English
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Summary:A magnetic molecularly imprinted polymer (MMIP) was synthesized and tested for an rheumatoid arthritis (RA) rat model. Magnetite coated with mesoporous silica (Fe O @mSi) was used as core for surface imprinting, dopamine was used as monomer and methotrexate (MTX) was loaded directly during polymerization. The amount of MTX loaded on MMIPs reached 201.165 ± 0.315 µmol/g. Characterization of the polymers was done via SEM, TEM and FTIR. The pharmacological effect of the selected MMIP was evaluated in a Complete Freund's Adjuvant (CFA) induced arthritis rat model where a 3D magnet bearing construct was designed for targeted delivery of MMIPs. The parameters evaluated were the change in paw edema, paw diameter, gait score and animal's weight. Results revealed a tendency of MMIP to significantly improve the measured parameters which was confirmed with histopathological findings. In conclusion, the improvement in the arthritic signs associated with MMIP treatment compared to free MTX, indicated successful targeting of MMIPs to site of inflammation.
ISSN:1061-186X
1029-2330
DOI:10.1080/1061186X.2023.2247584