Effect of caffeine on hippocampal memory and levels of gene expression in social isolation stress

Caffeine (Cf) antagonizes the adenosine receptors and has neuroprotective properties. The effect of Cf has been seen on stress-induced deficits of cognitive. In this study, we have investigated the effect of Cf on learning and memory functions induced by social isolation (SI) stress. In the present...

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Bibliographic Details
Published in:International journal of developmental neuroscience 2023-11, Vol.83 (7), p.641-652
Main Authors: Musuroglu Keloglan, Seval, Sahin, Leyla, Kocahan, Sayad, Annac, Ebru, Tirasci, Nurhan, Pekmezekmek, Ayper Boga
Format: Article
Language:English
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Summary:Caffeine (Cf) antagonizes the adenosine receptors and has neuroprotective properties. The effect of Cf has been seen on stress-induced deficits of cognitive. In this study, we have investigated the effect of Cf on learning and memory functions induced by social isolation (SI) stress. In the present study, 21-day-old Wistar albino male rats (n = 28) were divided into four groups: the control (C), the SI, the Cf, and the social isolation + caffeine (SICf). Cf (0.3 g/L) was added to the drinking water of the experimental animals for 4 weeks. The learning and memory functions were assessed using the Morris Water Maze Test (MWMT). Following, was performed histopathological evaluation and determined hippocampal gene expression levels by RT-qPCR. According to MWMT findings, the time spent in the quadrant where the platform removed was decreased in the SI group compared with the C (p 
ISSN:0736-5748
1873-474X
DOI:10.1002/jdn.10292