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First evidence of in vivo effect of FLASH radiotherapy with helium ions in zebrafish embryos

Highlights•Irradiation of zebrafish embryos with helium ions at 18–24 Gy impairs development. •UHDR irradiation spares development compared to conv-dose RT. •First evidence of in vivo “FLASH” effect with helium ions.

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Bibliographic Details
Published in:Radiotherapy and oncology 2023-10, Vol.187, p.109820-109820, Article 109820
Main Authors: Ghannam, Youssef, Chiavassa, Sophie, Saade, Gaëlle, Koumeir, Charbel, Blain, Guillaume, Delpon, Grégory, Evin, Manon, Haddad, Ferid, Maigne, Lydia, Mouchard, Quentin, Servagent, Noël, Potiron, Vincent, Supiot, Stéphane
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Language:English
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Summary:Highlights•Irradiation of zebrafish embryos with helium ions at 18–24 Gy impairs development. •UHDR irradiation spares development compared to conv-dose RT. •First evidence of in vivo “FLASH” effect with helium ions.
ISSN:0167-8140
1879-0887
1879-0887
DOI:10.1016/j.radonc.2023.109820