Open tubular liquid chromatography: Recent advances and future trends

Nano‐liquid chromatography (nanoLC) is gaining significant attention as a primary analytical technique across various scientific domains. Unlike conventional high‐performance LC, nanoLC utilizes columns with inner diameters (i.ds.) usually ranging from 10 to 150 μm and operates at mobile phase flow...

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Bibliographic Details
Published in:Journal of separation science 2023-09, Vol.46 (18), p.e2300373-e2300373
Main Authors: Medina, Deyber Arley Vargas, Cardoso, Alessandra Timoteo, Borsatto, João Victor Basolli, Lanças, Fernando Mauro
Format: Article
Language:English
Subjects:
Chromatography
Liquid chromatography
Packed columns
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Summary:Nano‐liquid chromatography (nanoLC) is gaining significant attention as a primary analytical technique across various scientific domains. Unlike conventional high‐performance LC, nanoLC utilizes columns with inner diameters (i.ds.) usually ranging from 10 to 150 μm and operates at mobile phase flow rates between 10 and 1000 nl/min, offering improved chromatographic performance and detectability. Currently, most exploration of nanoLC has focused on particle‐packed columns. Although open tubular LC (OTLC) can provide superior performance, optimized OTLC columns require very narrow i.ds. (
ISSN:1615-9306
1615-9314
DOI:10.1002/jssc.202300373