Optical coherence tomography angiography analysis of changes in the retina and the choroid after hemodialysis for end stage kidney disease

• Published in: International ophthalmology 2023-12, Vol.43 (12), p.4473-4479
• Main Authors: Zegrari, Samira, Mouallem, Alexandra, Audard, Vincent, Jouan, Narindra, Grimbert, Philippe, Jung, Camille, Sakhi, Hichem, Souied, Eric H., Miere, Alexandra
• Format: Article
• Language: English
• Subjects: Adult; Aged; Angiography; Choroid - blood supply; Density; End-stage renal disease; Female; Fluorescein Angiography - methods; Hemodialysis; Humans; Kidney diseases; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - therapy; Kidneys; Male; Medical imaging; Medicine; Medicine & Public Health; Middle Aged; Ophthalmology; Optic nerve; Optical Coherence Tomography; Original Paper; Patients; Perfusion; Prospective Studies; Rank tests; Renal Dialysis - adverse effects; Retina; Retinal Vessels - diagnostic imaging; Thickness measurement; Tomography; Tomography, Optical Coherence - methods
• ISSN: 1573-2630; 0165-5701; 1573-2630
• DOI: 10.1007/s10792-023-02847-3

Purpose To study effects of hemodialysis (HD) on retinal and choroidal vasculature in patients with end-stage kidney disease (ESKD) using optical coherence tomography angiography (OCTA). Methods In this prospective study, we investigated eyes of patients undergoing hemodialysis for ESKD from Mondor University Hospital. Only one eye/patient was considered. Subfoveal choroidal thickness (SCT) was measured on enhanced-depth imaging optical coherence tomography (EDI-OCT) before and after the hemodialysis session. OCTA was used to extract retinal vascular density (superficial and deep capillary plexus, SCP, DCP) and choriocapillaris non-perfusion. Clinical, demographic and biological parameters (Blood B-Nitric Peptid rate prior to HD session) were reviewed. Results Twenty patients (mean age 53.2 ± 13.6 years, 10 males and 10 females) were included in this prospective study. SCT significantly decreased after the HD session (234.3 ± 56.14 µm before HD to 211.9 ± 60.79 µm after hemodialysis (Wilcoxon signed-rank test, p  = 0.003)). Non-perfusion in the choriocapillaris significantly increased after HD (41.65 ± 3.58 before HD, 42.95 ± 3.19 after HD, p  = 0.036) while no significant modification of the vascular density was observed in the retinal vasculature (SCP, DCP) around the macular zone or the optic nerve. An increased plasma B-Nitric Peptide (BNP) level prior to the onset of the HD session was significantly correlated with the decrease of the SCT ( r  = 0.45, p  = 0.043). Conclusion Hemodialysis in patients with ESKD is associated with a significant decrease in SCT and an increase in non-perfusion in the choriocapillaris on OCTA. A High BNP level prior to the onset of the hemodialysis appears to be correlated with the decrease in SCT.