Systemic inflammation response index predicts the postoperative recurrence of chronic rhinosinusitis with nasal polyps: a retrospective study in the Chinese population

• Published in: European archives of oto-rhino-laryngology 2024, Vol.281 (1), p.207-217
• Main Authors: Yang, Yuqing, Zhu, Jing, Zhang, Mengyu, Wang, Yihong, Cheng, Fuwei, Ma, Wenxia, Li, Manyi
• Format: Article
• Language: English
• Subjects: China - epidemiology; Chronic Disease; Head and Neck Surgery; Humans; Inflammation; Medicine; Medicine & Public Health; Nasal Polyps - complications; Nasal Polyps - epidemiology; Nasal Polyps - surgery; Neurosurgery; Otorhinolaryngology; Retrospective Studies; Rhinitis - complications; Rhinitis - epidemiology; Rhinitis - surgery; Rhinology; Rhinosinusitis; Sinusitis - complications; Sinusitis - epidemiology; Sinusitis - surgery
• ISSN: 0937-4477; 1434-4726
• DOI: 10.1007/s00405-023-08182-8

Purpose Endoscopic sinus surgery (ESS) is now frequently used to treat chronic sinusitis with nasal polyps (CRSwNP), but postoperative recurrence plagues many patients. We aimed to assess the value of the systemic inflammation response index (SIRI) and the systemic immune-inflammatory index (SII) for the prediction of postoperative recurrence in patients with CRSwNP. Methods A total of 143 patients with CRSwNP and 76 age- and sex-matched healthy subjects were enrolled. Patients were divided into the recurrence group and the non-recurrence group according to the recurrence of CRSwNP. Univariate and multivariate analyses showed independent risk factors for the recurrence. A receiver operating characteristic curve analysis was conducted to assess the predictive accuracy of the variables and determine the optimal cut-off values. Finally, a survival analysis was conducted. Results Univariate analysis revealed that age, sex, CRP, EOS, SIRI, SII, NLR, ELR, and Lund–Mackay CT scores were significant predictors of the recurrence of CRSwNP. Multivariate analysis confirmed that SIRI (OR = 1.310, p