Recent Efforts in Identification of Privileged Scaffolds as Antiviral Agents

Viral infections are the most important health concern nowadays to mankind, which is unexpectedly increasing the health complications and fatality rate worldwide. The recent viral infection outbreak developed a pressing need for small molecules that can be quickly deployed for the control/treatment...

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Bibliographic Details
Published in:Chemistry & biodiversity 2023-10, Vol.20 (10), p.e202300921-n/a
Main Authors: Yadav, Yogesh, Singh, Kavita, Sharma, Sunil, Mishra, Vinay Kumar, Sagar, Ram
Format: Article
Language:English
Subjects:
Anti-HIV
Anti-SARS
Antiviral agents
Drug development
Drug resistance
Drugs
Exo-a-sialidase
Hepatitis
HIV
Human immunodeficiency virus
Molecular docking
Natural products
Neuraminidase
Scaffolds
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Viral diseases
Viral infections
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Summary:Viral infections are the most important health concern nowadays to mankind, which is unexpectedly increasing the health complications and fatality rate worldwide. The recent viral infection outbreak developed a pressing need for small molecules that can be quickly deployed for the control/treatment of re‐emerging or new emerging viral infections. Numerous viruses, including the human immunodeficiency virus (HIV), hepatitis, influenza, SARS‐CoV‐1, SARS‐CoV‐2, and others, are still challenging due to emerging resistance to known drugs. Therefore, there is always a need to search for new antiviral small molecules that can combat viral infection with new modes of action. This review highlighted recent progress in developing new antiviral molecules based on natural product‐inspired scaffolds. Herein, the structure‐activity relationship of the FDA‐approved drugs along with the molecular docking studies of selected compounds have been discussed against several target proteins. The findings of new small molecules as neuraminidase inhibitors, other than known drug scaffolds, Anti‐HIV and SARS‐CoV are incorporated in this review paper.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202300921