Takotsubo Syndrome, Stressful Triggers, and Risk of Recurrence

The risk of recurrence in takotsubo syndrome (TTS) appears to be low, although previous studies have shown conflicting results and factors associated with recurrences are unclear. The aim of this study is to evaluate the incidence and predictors of TTS recurrences. Adult patients included in the Spa...

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Published in:The American journal of cardiology 2023-10, Vol.205, p.58-62
Main Authors: Fernández-Cordón, Clara, Núñez-Gil, Iván Javier, Martín de Miguel, Irene, Pérez-Castellanos, Alberto, Vedia, Oscar, Almendro-Delia, Manuel, López-País, Javier, Uribarri, Aitor, Duran-Cambra, Albert, Martín-García, Agustín, Raposeiras-Roubin, Sergio, Blanco-Ponce, Emilia, Corbí-Pascual, Miguel, Guillén Marzo, Marta, Andrés, Mireia, Feltes, Gisela, Martínez-Selles, Manuel
Format: Article
Language:English
Subjects:
Catecholamines
Ejection fraction
Medical records
Mortality
Pathophysiology
recurrences
Regression models
Statistical analysis
stressful triggers
takotsubo syndrome
Variables
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Summary:The risk of recurrence in takotsubo syndrome (TTS) appears to be low, although previous studies have shown conflicting results and factors associated with recurrences are unclear. The aim of this study is to evaluate the incidence and predictors of TTS recurrences. Adult patients included in the Spanish Multicenter REgistry of TAKOtsubo syndrome (RETAKO) between January 2003 and September 2019 were identified. Patients were categorized based on recurrences during follow-up and a multivariate logistic regression model was used to identify factors associated with recurrences. A total of 1097 patients (mean age 71.0±11.9 years, 87% females) were included, repeated TTS events were documented in 44 patients (4.0%), including 13 patients with prior TTS and 31 patients with recurrent TTS during a median follow-up of 279 days. Two patients (0.02%) had two episodes of recurrence. Compared to patients who had no recurrence of TTS, those with recurrent TTS more frequently had no identifiable stressful trigger in the index admission (20 [64.5%] vs 352 [33.0%], p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2023.07.155