Bone erosions associated with systemic bone loss on HR-pQCT in women with longstanding polyarticular juvenile idiopathic arthritis

To analyze longstanding polyarticular juvenile idiopathic arthritis (pJIA) for possible associations between localized bone damage (erosions), and systemic bone loss. Besides, to compare the systemic bone mass of pJIA with healthy controls. Thirty-four pJIA women and 99 healthy controls (HC) were in...

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Published in:Seminars in arthritis and rheumatism 2023-12, Vol.63, p.152247-152247, Article 152247
Main Authors: Ribeiro, Surian Clarisse C R, Sales, Lucas P, Fernandes, Alan L, Perez, Mariana O, Takayama, Liliam, Caparbo, Valeria F, Assad, Ana Paula L, Aiwaka, Nadia E, Goldenstein-Schainberg, Cláudia, Borba, Eduardo F, Domiciano, Diogo S, Figueiredo, Camille P, Pereira, Rosa Mr
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Adult
Arthritis, Juvenile - complications
Arthritis, Juvenile - diagnostic imaging
Bone Density
Female
Humans
Osteoporosis
Radius
Tibia - diagnostic imaging
Tomography, X-Ray Computed
Young Adult
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Summary:To analyze longstanding polyarticular juvenile idiopathic arthritis (pJIA) for possible associations between localized bone damage (erosions), and systemic bone loss. Besides, to compare the systemic bone mass of pJIA with healthy controls. Thirty-four pJIA women and 99 healthy controls (HC) were included. Radius and tibia of all subjects were scanned by HR-pQCT. Volumetric bone mineral density (vBMD), bone microarchitecture, and -finite element parameters were analyzed. Patients underwent HR-pQCT of 2nd and 3rd metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints of the dominant hand, for bone erosions quantification. The mean age of patients was 31.5 ± 7.4yrs with a mean disease duration of 21.7 ± 9.2yrs. Bone erosions were detectable in 79% of patients. The number of bone erosions was positively correlated with cortical porosity (Ct.Po) at tibia (r = 0.575, p = 0.001), and radius (r = 0.423, p = 0.018); and negatively correlated with cortical vBMD at tibia (r=-0.420, p = 0.015). In a logistic regression analysis, adjusted for anti-CCP, the presence of bone erosions was independently associated with Ct.Po at radius (p = 0.018) and cortical vBMD at tibia (p = 0.020). Moreover, cortical and trabecular vBMD, trabecular number, and μ-finite element parameters were decreased in patients compared to HC (p 
ISSN:0049-0172
1532-866X
DOI:10.1016/j.semarthrit.2023.152247