Integrated analyses reveal the prognostic, immunological features and mechanisms of cuproptosis critical mediator gene FDX1 in KIRC

The ferredoxin 1 (FDX1) gene had been recently reported as a critical mediator of cuproptosis, and without doubt, its roles in KIRC would be of importance. Hence, this paper was to explore the roles of FDX1 in kidney renal clear cell carcinoma (KIRC) and its potential molecular mechanisms via scRNA-...

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Bibliographic Details
Published in:Genes and immunity 2023-08, Vol.24 (4), p.171-182
Main Authors: Wang, Yi, Zhang, Xinyu, Chen, Guihua, Xing, Qianwei, Zhu, Bingye, Wang, Xiang
Format: Article
Language:English
Subjects:
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45/77
631/208/68
631/208/721
Biomedical and Life Sciences
Biomedicine
Cancer Research
Ferredoxin
Gene Expression
Gene set enrichment analysis
Human Genetics
Immunity
Immunology
Immunotherapy
Medical prognosis
Molecular modelling
mRNA
Non-coding RNA
Prognosis
Renal cell carcinoma
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Summary:The ferredoxin 1 (FDX1) gene had been recently reported as a critical mediator of cuproptosis, and without doubt, its roles in KIRC would be of importance. Hence, this paper was to explore the roles of FDX1 in kidney renal clear cell carcinoma (KIRC) and its potential molecular mechanisms via scRNA-sequencing and bulk RNA-sequencing analyses. FDX1 was lowly expressed in KIRC and validated both at the protein and mRNA levels (all p  
ISSN:1476-5470
1466-4879
1476-5470
DOI:10.1038/s41435-023-00211-0