The behavioral, pathological and therapeutic features of the triple transgenic Alzheimer's disease (3 × Tg-AD) mouse model strain

As a classic animal model of Alzheimer's disease (AD), the 3 × Tg-AD mouse not only recapitulates most of anatomical hallmarks observed in AD pathology but also displays cognitive alterations in memory and learning tasks. The 3 × Tg-AD can better show the two characteristics of AD, amyloid β (A...

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Bibliographic Details
Published in:Experimental neurology 2023-10, Vol.368, p.114505-114505, Article 114505
Main Authors: Tian, Sheng, Ye, Tianyuan, Cheng, Xiaorui
Format: Article
Language:English
Subjects:
3 × Tg-AD mice
Alzheimer's disease
Cognition
Learning and memory
Tau hyperphosphorylation
β-Amyloid deposit
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Summary:As a classic animal model of Alzheimer's disease (AD), the 3 × Tg-AD mouse not only recapitulates most of anatomical hallmarks observed in AD pathology but also displays cognitive alterations in memory and learning tasks. The 3 × Tg-AD can better show the two characteristics of AD, amyloid β (Aβ) and neurofibrillary tangles (NFT). Therefore, 3 × Tg-AD strain is widely used in AD pathogenesis research and new drug development of AD. In this paper, the construction methods, pathological changes, and treatment characteristics of 3 × Tg-AD mouse models commonly used in AD research are summarized and commented, hoping to provide reference for researchers to choose and establish experimental patterns.
ISSN:0014-4886
1090-2430
DOI:10.1016/j.expneurol.2023.114505