A predictive survival model for patients with stage IV oropharyngeal squamous cell carcinoma treated with chemoradiation

Purpose To evaluate the pre-treatment and post-treatment clinical factors associated with rate of survival at 1, 3, and 5 years in stage IV oropharyngeal cancer patients treated with concurrent chemoradiation with/without neoadjuvant chemotherapy. Methods This retrospective cohort study involved 128...

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Published in:European archives of oto-rhino-laryngology 2024, Vol.281 (1), p.369-377
Main Authors: Yeh, Peng, Chang, Chih-Ming, Liao, Li-Jen, Wu, Chia-Yun, Hsieh, Chen-Hsi, Shueng, Pei-Wei, Cheng, Po-Wen, Lo, Wu-Chia
Format: Article
Language:English
Subjects:
Head and Neck
Head and Neck Neoplasms
Head and Neck Surgery
Humans
Inflammation - pathology
Medicine
Medicine & Public Health
Melanoma
Neurosurgery
Oropharyngeal Neoplasms - therapy
Otorhinolaryngology
Prognosis
Retrospective Studies
Skin Neoplasms
Squamous Cell Carcinoma of Head and Neck
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Summary:Purpose To evaluate the pre-treatment and post-treatment clinical factors associated with rate of survival at 1, 3, and 5 years in stage IV oropharyngeal cancer patients treated with concurrent chemoradiation with/without neoadjuvant chemotherapy. Methods This retrospective cohort study involved 128 Stage IV oropharyngeal cancer patients that were treated at our tertiary referral center between 2008 and 2020. The pre-treatment and post-treatment clinical parameters including nutritional status and inflammatory markers were retrospectively reviewed. Results The 5-year overall survival rate for all patients was 36.72%. The disease-specific survival (DSS) at 1-year and 3-year were 80% and 63%, whereas the disease-free survival (DFS) at 1-year and 3-year were 49% and 40%, respectively. In multivariate analyses, pretreatment hemoglobin (Hb) 
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-023-08187-3