Rapid detection of synthetic cannabinoid receptor agonists impregnated into paper by attenuated total reflectance Fourier transform infrared spectroscopy

The last few years have witnessed the change in the modalities of smuggling of synthetic cannabinoid receptor agonists (SCRAs) by impregnating them in mail envelopes and fast parcels. Considering the aforementioned scenario, it is important to develop a portable technique to identifying SCRAs throug...

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Bibliographic Details
Published in:Journal of forensic sciences 2023-11, Vol.68 (6), p.1906-1912
Main Authors: Coombs, Thomas, Abdelkader, Amor, Tang, Leung, Al‐Jumeily, Dhiya, Assi, Sulaf
Format: Article
Language:English
Subjects:
Algorithms
Caffeine
Clustering
Crystallization
Data analysis
Fourier transforms
Infrared spectroscopy
Least squares method
Packages
Principal components analysis
Receptors
Reflectance
Smuggling
Spectrum analysis
Substrates
Variable thickness
Wavelengths
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Summary:The last few years have witnessed the change in the modalities of smuggling of synthetic cannabinoid receptor agonists (SCRAs) by impregnating them in mail envelopes and fast parcels. Considering the aforementioned scenario, it is important to develop a portable technique to identifying SCRAs through packages. The purpose of this research was to detect SCRAs impregnated into substrates of paper using attenuated total reflectance Fourier transform infrared (ATR‐FTIR) spectroscopy. Three SCRAs that included 5F‐PB‐22, AB‐FUBINACA and AKB‐48 were purchased from Sigma Aldrich. The three SCRAs and four cutting agents were impregnated into paper of variable thickness at four concentrations (10, 15, 20, and 25 mg/mL). Spectra were collected over the wavenumber range of 650–4000 cm −1 using ATR‐FTIR spectroscopy and were exported to Matlab 2020b where data analysis was applied. The FTIR spectral data was able to show the three SCRAs could be detected on paper using ATR‐FTIR spectroscopy and quantitatively modeled using the partial least squares regression algorithm. Principal component analysis showed separate clustering for the compounds that crystallized (5F‐PB‐22, AB‐FUBINACA and caffeine) onto the papers surface from those impregnated into the bulk of the paper (AKB‐48 and procaine) with the latter situated near blank papers in score plots. In summary, ATR‐FTIR spectroscopy has proven to be a successful non‐destructive technique in detecting and quantifying a selection of SCRAs impregnated into paper.
ISSN:0022-1198
1556-4029
DOI:10.1111/1556-4029.15346