Multi-drug resistance pattern of bacterial isolates from urinary tract infection

• Published in: Pakistan journal of pharmaceutical sciences 2023-07, Vol.36 (4), p.1107-1112
• Main Authors: Asghar, Faiza, Muhammad, Sardar, Anjum, Aftab Ahmad, Ali, Tehreem, Asghar, Abdul Shaheed, Naureen, Sobia, Manzoor, Rabia
• Format: Article
• Language: English
• Subjects: Bacterial infections; Development and progression; Drug resistance in microorganisms; Drug therapy; Testing; Urinary tract infections
• ISSN: 1011-601X
• DOI: 10.36721/PJPS.2023.36.4.REG.1107-1112.1

In the community and among hospitalized patients, urinary tract infections (UTIs) rank as the most common bacterial infections. The researchers processed urine samples obtained from affiliated hospitals of Peshawar Medical College. The samples were examined under a microscope to assess the presence of bacteria, pus cells and red blood cells. Following this, the samples were inoculated on MacConkey and blood agar and subsequent antibiotic susceptibility testing was conducted. The findings revealed that 35.9% of hospitalized patients and 16.9% of outpatients were diagnosed with UTIs. Furthermore, 82.2% of the identified UTIs were found to be multidrug-resistant (MDR), with MDR Escherichia coli accounting for 77% of cases. Trimethoprim sulfamethazine (26.8%), penicillin (0%), cefepime (27.8%), cefotaxime (23.7%), aztreonam (2.1%), meropenem (86.6%), ciprofloxacin (51.5%), amoxicillin/clavulanic acid (37.1%), nitrofurantoin (70.1%), gentamycin (73%), ceftazidime (19.5%), levofloxacin (51.5%) and ceftriaxone (25.77%) were subjected to antibiotic susceptibility testing. It is concerning that among the 13 antibiotics examined, solely nitrofurantoin displayed oral efficacy as an effective treatment choice for UTIs. Keywords: Analytical profile index, antibiotic susceptibility, multidrug- resistant organisms, nitrofurantoin, urinary tract infection.