Probiotic components of Bacillus siamensis LF4 mitigated β-conglycinin caused cell injury via modulating TLR2/MAPKs/NF-κB signaling in Lateolabrax maculatus

β-conglycinin is a recognized factor in leading to intestinal inflammation and limiting application of soybean meal in aquaculture. Our previous study reported that heat-killed B. siamensis LF4 could effectively mitigate inflammatory response and apoptosis caused by β-conglycinin in spotted seabass...

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Published in:Fish & shellfish immunology 2023-10, Vol.141, p.109010-109010, Article 109010
Main Authors: Liu, Zi-Yan, Yang, Hong-Ling, Li, Sha, Cai, Guo-He, Ye, Ji-Dan, Zhang, Chun-Xiao, Sun, Yun-Zhang
Format: Article
Language:English
Subjects:
Apoptosis
Bacillus siamensis
Enterocytes
Inflammation
Lateolabrax maculatus
TLR2/MAPKs/NF-κB signaling
β-conglycinin
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Summary:β-conglycinin is a recognized factor in leading to intestinal inflammation and limiting application of soybean meal in aquaculture. Our previous study reported that heat-killed B. siamensis LF4 could effectively mitigate inflammatory response and apoptosis caused by β-conglycinin in spotted seabass (Lateolabrax maculatus) enterocytes, but the mechanisms involved are not fully understood. In the present study, therefore, whole cell wall (CW), peptidoglycan (PG) and lipoteichoic acid (LTA) and cell-free supernatant (CFS) have been collected from B. siamensis LF4 and their mitigative function on β-conglycinin-induced adverse impacts and mechanisms underlying were evaluated. The results showed that β-conglycinin-induced cell injury, characterized with significantly decreased cell viability and increased activities of lactate dehydrogenase, glutamic oxaloacetic transaminase, glutamic propylic transaminase (P 
ISSN:1050-4648
1095-9947
DOI:10.1016/j.fsi.2023.109010