Sensitivity of hostile hemodynamics to aneurysm geometry via unsupervised shape interpolation

• Published in: Computer methods and programs in biomedicine 2023-11, Vol.241, p.107762-107762, Article 107762
• Main Authors: MacDonald, Daniel E., Cancelliere, Nicole M., Pereira, Vitor M., Steinman, David A.
• Format: Article
• Language: English
• Subjects: Computational fluid dynamics; Geometry; Intracranial aneurysm; Machine learning; Morphology; Uncertainty quantification
• ISSN: 0169-2607; 1872-7565
• DOI: 10.1016/j.cmpb.2023.107762

•A deep neural network can construct plausible cohorts of aneurysm geometries.•Sac-average wall shear stress may share too much mutual information with geometry.•Conversely, some metrics of complex flow may be too sensitive to geometry. Vessel geometry and hemodynamics are intrinsically linked, whereby geometry determines hemodynamics, and hemodynamics influence vascular remodeling. Both have been used for testing clinical outcomes, but geometry/morphology generally has less uncertainty than hemodynamics derived from medical image-based computational fluid dynamics (CFD). To provide clinical utility, CFD-based hemodynamic parameters must be robust to modeling errors and/or uncertainties, but must also provide useful information not more-easily extracted from shape alone. The objective of this study was to methodically assess the response of hemodynamic parameters to gradual changes in shape created using an unsupervised 3D shape interpolation method. We trained the neural network NeuroMorph on 3 patient-derived intracranial aneurysm surfaces (labelled A, B, C), and then generated 3 distinct morph sequences (A→B, B→C, C→A) each containing 10 interpolated surfaces. From high-fidelity CFD simulation of these, we calculated a variety of common reduced hemodynamic parameters, including many previously associated with aneurysm rupture, and analyzed their responses to changes in shape, and their correlations. The interpolated surfaces demonstrate complex, gradual changes in branch angles, vessel diameters, and aneurysm morphology. CFD simulation showed gradual changes in aneurysm jetting characteristics and wall-shear stress (WSS) patterns, but demonstrated a range of responses from the reduced hemodynamic parameters. Spatially and temporally averaged parameters including time-averaged WSS, time-averaged velocity, and low-shear area (LSA) showed low variation across all morph sequences, while parameters of flow complexity such as oscillatory shear, spectral broadening, and spectral bandedness indices showed high variation between slightly-altered neighboring surfaces. Correlation analysis revealed a great deal of mutual information with easier-to-measure shape-based parameters. In the absence of large clinical datasets, unsupervised shape interpolation provides an ideal laboratory for exploring the delicate balance between robustness and sensitivity of nominal hemodynamic predictors of aneurysm rupture. Parameters like time-averaged WSS and LSA that are highly “r