Exploring the recent developments of alginate silk fibroin material for hydrogel wound dressing: A review

• Published in: International journal of biological macromolecules 2023-09, Vol.248, p.125989-125989, Article 125989
• Main Authors: Zahra, Duaa, Shokat, Zeeshan, Ahmad, Azka, Javaid, Anam, Khurshid, Mohsin, Ashfaq, Usman Ali, Nashwan, Abdulqadir J.
• Format: Article
• Language: English
• Subjects: Alginate; Alginate silk fibroin material; Polymeric; Wound dressing
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2023.125989

Hydrogels, a type of polymeric material capable of retaining water within a three-dimensional network, have demonstrated their potential in wound healing, surpassing traditional wound dressings. These hydrogels possess remarkable mechanical, chemical, and biological properties, making them suitable scaffolds for tissue regeneration. This article aims to emphasize the advantages of alginate, silk fibroin, and hydrogel-based wound dressings, specifically highlighting their crucial functions that accelerate the healing process of skin wounds. Noteworthy functions include self-healing ability, water solubility, anti-inflammatory properties, adhesion, antimicrobial properties, drug delivery, conductivity, and responsiveness to stimuli. Moreover, recent advancements in hydrogel technology have resulted in the development of wound dressings with enhanced features for monitoring wound progression, further augmenting their effectiveness. This review emphasizes the utilization of hydrogel membranes for treating excisional and incisional wounds, while exploring recent breakthroughs in hydrogel wound dressings, including nanoparticle composite hydrogels, stem cell hydrogel composites, and curcumin-hydrogel composites. Additionally, the review focuses on diverse synthesis procedures, designs, and potential applications of hydrogels in wound healing dressings. [Display omitted]