Neural substrates for dissociation of cognition inhibition in autogenous- and reactive-type obsessive-compulsive disorder

• Published in: Journal of psychiatric research 2023-09, Vol.165, p.150-157
• Main Authors: Fan, Jie, Xia, Jie, Liu, Qian, Wang, Xiang, Du, Hongyu, Gao, Feng, Han, Yan, Yu, Quanhao, Lu, Jingjie, Xiao, Chuman, Tan, Changlian, Zhu, Xiongzhao
• Format: Article
• Language: English
• Subjects: Autogenous-reactive obsessions; Cognition inhibition; Functional connectivity; Heterogeneity; Response inhibition
• ISSN: 0022-3956; 1879-1379
• DOI: 10.1016/j.jpsychires.2023.07.031

The taxonomy of autogenous- and reactive-type obsessive-compulsive disorder (OCD) (AO vs. RO) is one of the most valid subtyping approaches to the heterogeneity of OCD. The present study aimed to seek evidence of neural substrates supporting the dissociation of cognition inhibition in AO and RO which was revealed by our previous behavioral and electrophysiological work. A total of 165 patients with OCD (86 AO versus 79 RO), and 79 healthy controls (HC) underwent resting-state functional magnetic resonance imaging scans. Within-network connectivity, node strength, and edge-wise functional connectivity (FC) in cognition and response inhibition networks were calculated. Results from 3 cognition and 2 response inhibition network atlases were compared to confirm the robustness of the findings. Both AO and RO showed lower within-network connectivity in response inhibition networks, while lower within cognition inhibition network connectivity was only detected in AO. Besides shared weaker node strength in the anterior insula (AI), anterior cingulate cortex (ACC), and supplementary motor area (SMA), AO had a broader range of nodes within cognition inhibition networks exhibiting weaker strength, including nodes in right inferior frontal gyrus (IFG), left parietal and occipital regions. Decreased FC of left AI-CC, left IFG-ACC, and frontal-parietal regions in cognition inhibition networks were found in AO. Findings indicate that unlike deficits in connectivity within response inhibition networks which may reflect a common pathology in AO and RO, deficits in connectivity within cognition inhibition networks were more pronounced in AO. These findings strengthen our insight into the heterogeneity in OCD. •Both AO and RO demonstrated lower within response inhibition network connectivity.•Weaker within cognition inhibition network connectivity was only detected in AO.•AO had more nodes within cognition inhibition network exhibiting weaker strength.•Weaker FC between frontoparietal regions within inhibition networks were found in AO.•Findings strengthened our insight into the heterogeneity in OCD.