Washed microbiota transplantation improves haemoglobin levels in anaemia of chronic disease

Background Anaemia of chronic disease (ACD) is the second most common type of anaemia and lacks an effective treatment. Patients with anaemia are reported to have altered gut microbial profiles, which may affect erythropoiesis. Here, we investigated the gut microbial features of patients with ACD an...

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Bibliographic Details
Published in:European journal of clinical investigation 2023-12, Vol.53 (12), p.e14072-n/a
Main Authors: Zhong, Hao‐Jie, Chen, Wei‐Ran, Lu, Xin‐Jian, Hu, Dong‐Xia, Lin, De‐Jiang, Liu, Tao, Wu, Lei, Wu, Li‐Hao, He, Xing‐Xiang
Format: Article
Language:English
Subjects:
Abundance
anaemia
Anemia
butyrates
chronic disease
Chronic illnesses
Composition
Erythropoiesis
faecal microbiota transplantation
gut microbiota
haemoglobin
Hemoglobin
Intestinal microflora
Microbiota
Microorganisms
Transplantation
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Summary:Background Anaemia of chronic disease (ACD) is the second most common type of anaemia and lacks an effective treatment. Patients with anaemia are reported to have altered gut microbial profiles, which may affect erythropoiesis. Here, we investigated the gut microbial features of patients with ACD and determined whether regulating gut microbiota using washed microbiota transplantation (WMT) was effective in treating ACD. Methods We compared the gut microbiota profile of patients with ACD and healthy controls, evaluated the efficacy of WMT on haematological parameters in the patients, and analysed the alterations in gut microbiota after WMT treatment. Results Patients with ACD had lower gut microbial richness, and differences in microbial composition and function, relative to healthy controls. Additionally, the relative abundances of two butyrate‐producing genera Lachnospiraceae NK4A136 group and Butyricicoccus, were positively correlated with the haemoglobin (HGB) level and lower in patients with ACD than controls. WMT significantly increased HGB levels in patients with ACD. After the first, second and third WMT rounds, normal HGB levels were restored in 27.02%, 27.78% and 36.37% (all p 
ISSN:0014-2972
1365-2362
DOI:10.1111/eci.14072