A Near-Infrared Colorimetric Fluorescent Probe for Ferrous Ion Detection and Imaging

Based on the N-redox mechanism, a turn-on near-infrared fluorescence probe ( SWJT-15 ) with cyano isophorone as skeleton was designed and synthesized for the detection of ferrous ions (Fe 2+ ). The probe has a lower detection limit (83 nM) and fast response (200 s) to Fe 2+ ions. And the probe has u...

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Bibliographic Details
Published in:Journal of fluorescence 2024-07, Vol.34 (4), p.1545-1550
Main Authors: Suo, Sheng-Nan, Tian, Yang, Tan, Wei-Lun, Lou, Xiao-Yang, Xu, Hai, Wang, Ya-Wen, Peng, Yu
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biomedicine
Biophysics
Biotechnology
Chemical synthesis
Colorimetry - methods
Ferrous Compounds - chemistry
Ferrous ions
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Fluorescent indicators
HeLa Cells
Humans
Infrared imaging
Infrared Rays
Ions - analysis
Iron - analysis
Limit of Detection
Molecular Structure
Optical Imaging
Spectrometry, Fluorescence
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Summary:Based on the N-redox mechanism, a turn-on near-infrared fluorescence probe ( SWJT-15 ) with cyano isophorone as skeleton was designed and synthesized for the detection of ferrous ions (Fe 2+ ). The probe has a lower detection limit (83 nM) and fast response (200 s) to Fe 2+ ions. And the probe has unique selectivity and good anti-interference performance against Fe 2+ ions compared to other metal ions. Moreover, the probe has been successfully applied to imaging Fe 2+ ions in HeLa cells.
ISSN:1053-0509
1573-4994
1573-4994
DOI:10.1007/s10895-023-03354-5