Knock‐out of multidrug efflux pump MexXY‐OprM results in increased susceptibility to antimicrobial peptides in Pseudomonas aeruginosa

Multidrug efflux systems of the resistance‐nodulation‐cell division family play a crucial role in resistance of Pseudomonas aeruginosa to a large variety of antibiotics. Here, we investigated the role of clinically relevant efflux pumps MexAB−OprM, MexCD−OprJ, and MexXY−OprM in resistance against di...

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Bibliographic Details
Published in:Microbiology and immunology 2023-09, Vol.67 (9), p.422-427
Main Authors: Neidig, Anke, Strempel, Nikola, Waeber, Nadine Bianca, Nizer, Waleska Stephanie da Cruz, Overhage, Joerg
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial peptides
Cationic antimicrobial peptides
Cell division
efflux pump
MexXY‐OprM
Multidrug resistance
Nodulation
Pseudomonas aeruginosa
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Summary:Multidrug efflux systems of the resistance‐nodulation‐cell division family play a crucial role in resistance of Pseudomonas aeruginosa to a large variety of antibiotics. Here, we investigated the role of clinically relevant efflux pumps MexAB−OprM, MexCD−OprJ, and MexXY−OprM in resistance against different cationic antimicrobial peptides (AMPs). Our results indicate that a knock‐out in efflux pump MexXY‐OprM increased susceptibility to some AMPs by two‐ to eightfold. Our data suggest a contribution of MexXY‐OprM in resistance to certain AMPs in P. aeruginosa, which should be considered in the future development of new and highly active antimicrobial peptides to fight multidrug resistant infections.
ISSN:0385-5600
1348-0421
DOI:10.1111/1348-0421.13089