Long-term outcome of cardiac resynchronization therapy patients in the elderly

Heart failure (HF) is a leading cause of mortality and hospitalization in the elderly. However, data are scarce about their response to device treatment such as cardiac resynchronization therapy (CRT). We aimed to evaluate the age-related differences in the effectiveness of CRT, procedure-related co...

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Bibliographic Details
Published in:GeroScience 2023-08, Vol.45 (4), p.2289-2301
Main Authors: Behon, Anett, Merkel, Eperke Dóra, Schwertner, Walter Richard, Kuthi, Luca Katalin, Veres, Boglárka, Masszi, Richard, Kovács, Attila, Lakatos, Bálint Károly, Zima, Endre, Gellér, László, Kosztin, Annamária, Merkely, Béla
Format: Article
Language:English
Subjects:
Age
Aged
Biomedical and Life Sciences
Cardiac Resynchronization Therapy - methods
Cell Biology
Congestive heart failure
Geriatrics/Gerontology
Heart transplantation
Humans
Life Sciences
Molecular Medicine
Mortality
Original Article
Retrospective Studies
Stroke Volume - physiology
Treatment Outcome
Ventricle
Ventricular Function, Left - physiology
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Summary:Heart failure (HF) is a leading cause of mortality and hospitalization in the elderly. However, data are scarce about their response to device treatment such as cardiac resynchronization therapy (CRT). We aimed to evaluate the age-related differences in the effectiveness of CRT, procedure-related complications, and long-term outcome. Between 2000 and 2020, 2656 patients undergoing CRT implantation were registered and analyzed retrospectively. Patients were divided into 3 groups according to their age: group I,  75 years. The primary endpoint was the echocardiographic response defined as a relative increase > 15% in left ventricular ejection fraction (LVEF) within 6 months, and the secondary endpoint was the composite of all-cause mortality, heart transplantation, or left ventricular assist device implantation. Procedure-related complications were also assessed. After implantation, LVEF showed significant improvement both in the total cohort [28% ( IQR 24/33) vs. 35% ( IQR 28/40); p  
ISSN:2509-2723
2509-2715
2509-2723
DOI:10.1007/s11357-023-00739-z