The co-existence of peripheral and vestibular neuropathy in diabetes: a cross-sectional study

Purpose Diabetic neuropathy can lead to decreased peripheral sensation and motor neuron dysfunction associated with impaired postural control and risk of falling. However, the relationship between decreased peripheral sensation and impaired vestibular function in diabetes mellitus is poorly investig...

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Published in:European archives of oto-rhino-laryngology 2024-02, Vol.281 (2), p.663-672
Main Authors: Mahalingasivam, Aksayan Arunanthy, Jespersen, Asger Krohn, Ejskjaer, Niels, Hougaard, Dan Dupont, Vestergaard, Peter, Rasmussen, Nicklas Højgaard-Hessellund, Røikjer, Johan
Format: Article
Language:English
Subjects:
Head and Neck Surgery
Medicine
Medicine & Public Health
Neurosurgery
Otology
Otorhinolaryngology
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Summary:Purpose Diabetic neuropathy can lead to decreased peripheral sensation and motor neuron dysfunction associated with impaired postural control and risk of falling. However, the relationship between decreased peripheral sensation and impaired vestibular function in diabetes mellitus is poorly investigated. Therefore, the aim of this study was to investigate the relationship between peripheral and autonomic measurements of diabetic neuropathy and measurements of vestibular function. Methods A total of 114 participants with type 1 diabetes ( n  = 52), type 2 diabetes ( n  = 51) and controls ( n  = 11) were included. Vestibular function was evaluated by video head impulse testing. Peripheral neuropathy was assessed by quantitative sensory testing and nerve conduction. Autonomic neuropathy using the COMPASS 31 questionnaire. Data were analyzed according to data type and distribution. Results Measurements of vestibular function did not differ between participants with type 1 diabetes, type 2 diabetes or controls (all p -values above 0.05). Subgrouping of participants according to the involvement of large-, small- or autonomic nerves did not change this outcome. Correlation analyses showed a significant difference between COMPASS 31 and right lateral gain value ( ρ  = 0.23, p  = 0.02,), while no other significant correlations were found. Conclusion Diabetic neuropathy does not appear to impair vestibular function in diabetes, by means of the VOR. Clinical trials NCT05389566, May 25th, 2022.
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-023-08130-6