Improvement in health perception but not quality of life with an antiseizure medication intervention in people with epilepsy in Guinea: A cohort study

•We studied quality of life and health perceptions in people with epilepsy in Guinea.•Free antiseizure medicines were given to patients with highly-active epilepsy.•Average quality of life scores were 52, 58, and 52 at baseline, 3, and 6 months.•Health perceptions improved but quality of life did no...

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Bibliographic Details
Published in:Seizure (London, England) England), 2023-10, Vol.111, p.30-35
Main Authors: Ham, Andrew Siyoon, Traore, Mohamed, Othon, Guelngar Carlos, Conde, Mohamed Lamine, Lamine, Toure Mohamed, Djigué, Barry Souleymane, Kaba, Condé, Karinka, Diawara, Idrissa, Doumbouya, Idrissa, Camara, Diallo, Djenabou, Duan, Rui, Rice, Dylan R., Cisse, Fode Abass, Mateen, Farrah J.
Format: Article
Language:English
Subjects:
Africa
Epilepsy
Health perception
Levetiracetam
Quality of life
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Summary:•We studied quality of life and health perceptions in people with epilepsy in Guinea.•Free antiseizure medicines were given to patients with highly-active epilepsy.•Average quality of life scores were 52, 58, and 52 at baseline, 3, and 6 months.•Health perceptions improved but quality of life did not by 6 months.•42% of PWE with seizures newly achieved seizure freedom during the study. : This study assesses perceptions of quality of life (QOL) and overall health in people with epilepsy (PWE) in Guinea after a clinical intervention providing modified and new antiseizure medicine (ASM) regimens. : Participants 12 years and older diagnosed with active epilepsy were prospectively and consecutively enrolled at two health centers in the Republic of Guinea (one urban, one rural) in 2022. 95% of participants were prescribed new/increased ASM doses, and interviewed for QOL and overall health perceptions at enrollment and three- and six-month follow ups. Univariate and linear mixed models were used to evaluate effects on QOL and overall health over time. : The mean QOLIE-31 score (±SD) among 148 Guinean PWE (82 male, 66 female; mean age 27.3; 137 with >1 seizure in prior year) was 51.7 ± 12.8 at enrollment, 57.6 ± 16.0 after three months (n = 116), and 52.2 ± 9.9 after six months (n = 87). Overall health scores were 53.1 ± 26.9, 72.6 ± 21.5, and 65.7 ± 20.2 respectively. After three months, PWE had improved overall health and QOLIE-31 scores (p
ISSN:1059-1311
1532-2688
DOI:10.1016/j.seizure.2023.07.008