Enantioanalysis of S-perindopril using different cyclodextrin-based potentiometric sensors

Construction of enantioselective, potentiometric membrane electrodes based on carbon-paste impregnated with α-, β- and γ-cyclodextrins as chiral selectors for the assay of S-perindopril is described. Response characteristics showed that the proposed electrodes could be reliably applied in the assay...

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Bibliographic Details
Published in:Sensors and actuators. B, Chemical Chemical, 2005-03, Vol.105 (2), p.425-429
Main Authors: Ozoemena, Kenneth I., Stefan, Raluca-Ioana, Staden, Jacobus F. van, Aboul-Enein, Hassan Y.
Format: Article
Language:English
Subjects:
Enantioselective assay
Enantioselective, potentiometric membrane electrode
S-perindopril
α-, β- and γ-cyclodextrins
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Summary:Construction of enantioselective, potentiometric membrane electrodes based on carbon-paste impregnated with α-, β- and γ-cyclodextrins as chiral selectors for the assay of S-perindopril is described. Response characteristics showed that the proposed electrodes could be reliably applied in the assay of S-perindopril raw material and its pharmaceutical formulation. The best enantioselectivity and time-stability were exhibited by α- and β- cyclodextrin based electrodes.
ISSN:0925-4005
1873-3077
DOI:10.1016/j.snb.2004.06.032